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Artist's impression of a base editor. K. Kim et al. (p 435) show that base-editing can efficiently create genetically modified mice, and Shimatani et al. (p 441) and Zong et al. (p 438) base-edit the genomes of crop plants. D. Kim et al. (p 475) present a genome-wide analysis of the specificity of a base editor. Image credit: Younghee Lee, CUBE3D graphic
Our personal ecosystem of microbes is shed on everything we touch and everyplace we go. Charles Schmidt reports on efforts to harness this information to improve human health and activity.
Biotechnology and chemistry researchers look to the patent literature as a source of technical information more than researchers in other fields, and few researchers are deterred from reading patents by concerns about enhanced legal liability.
Targeted editing of single base pairs is achieved in monocot rice and dicot tomato using Target-AID (Cas9 activation-induced cytidine deaminase fusion).