Volume 35 Issue 10, October 2017

Network of promoter–promoter and promoter–enhancer connectivity in the genome of a human cell line. The colors of the connections represent the different chromosomes; white dots correspond to protein-coding genes, green dots to lncRNAs and red dots to small RNAs. In this issue, Li et al. (p. 940) describe a method for the comprehensive mapping of the entire repertoire of chromatin-interacting RNAs and their respective binding sites and use it to infer regions of the genome that interact with each other. Credit: Bing Zhou.

Editorial

The key to unlocking CARs

Although Kymriah's approval represents a landmark for chimeric antigen receptor T-cell (CAR-T) therapy in B-cell malignancies, solid tumors remain a formidable challenge.

Editorial 11 Oct 2017

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News

Epic $12 billion deal and FDA's approval raise CAR-T to new heights

Elie Dolgin
News 11 Oct 2017
Novartis trial validates inflammasome as chronic disease driver

Cormac Sheridan
News 11 Oct 2017
First metabolic oncology inhibitor gets FDA green light, with record price tag

Ken Garber
News 11 Oct 2017
GM moths with autocidal gene tested outdoors in New York state

Emily Waltz
News 11 Oct 2017
23andMe wades further into drug discovery

Justin Petrone
News 11 Oct 2017
Speed and oversight: FDA Commissioner Gottlieb acts on pledges

Chris Morrison
News 11 Oct 2017
Around the world in a month

News 11 Oct 2017

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Bioentrepreneur

A successful founder off the beaten path

How to develop a new vaccine or therapeutic modality in a skeptical environment, with little biotech experience, limited resources and limited capital.

Ingmar Hoerr
Bioentrepreneur 11 Oct 2017

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Correspondence

iML1515, a knowledgebase that computes Escherichia coli traits

Jonathan M Monk
Colton J Lloyd
Bernhard O Palsson
Correspondence 11 Oct 2017
Antigen receptor repertoire profiling from RNA-seq data

Dmitriy A Bolotin
Stanislav Poslavsky
Dmitriy M Chudakov
Correspondence 11 Oct 2017

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Commentary

The grand challenge of cellulosic biofuels

Why cellulosic biofuels have fallen short of expectations and what we can do about it.

Lee R Lynd
Commentary 11 Oct 2017

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Patents

The Supreme Court's interpretation of the biosimilars statute and the value of certainty

The Supreme Court's decision in Sandoz v. Amgen introduces uncertainty into provisions that many viewed as necessary and enforceable, but its impact may ultimately be modest.

Irena Royzman
Nathan Monroe-Yavneh
Patents 11 Oct 2017
Recent patents related to the manufacture and repair of organs and organoids

Patents 11 Oct 2017

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News & Views

Mapping the secrets of the antibody pool

The progression of antibody-mediated immunity can now be monitored at high-throughput on a single-cell level.

Jonathan R McDaniel
Gregory C Ippolito
George Georgiou
News & Views 11 Sept 2017
Genetics of a hardy crop

New genomic resources for pearl millet are revealing how crops stand up to challenging environments.

Ksenia V Krasileva
News & Views 11 Oct 2017
Mosaic mice ace functional genomics

Markus Elsner
News & Views 11 Oct 2017
Research Highlights

News & Views 11 Oct 2017

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Review Article

Surge in insect resistance to transgenic crops and prospects for sustainability

Field-evolved resistance of pests to transgenic crops continues to emerge but can be delayed by using refuges as part of an integrated pest managent strategy.

Bruce E Tabashnik
Yves Carrière
Review Article 11 Oct 2017

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Brief Communication

Multiplexed quantification of proteins and transcripts in single cells

High-throughput quantification of protein and gene expression in single cells is achieved using DNA-barcoded antibodies.

Vanessa M Peterson
Kelvin Xi Zhang
Joel A Klappenbach
Brief Communication 30 Aug 2017

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Article

GRID-seq reveals the global RNA–chromatin interactome

The RNAs bound to the genome and their binding sites are detected with GRID-seq.

Xiao Li
Bing Zhou
Xiang-Dong Fu
Article 18 Sept 2017
Analysis of somatic microsatellite indels identifies driver events in human tumors

New computational tools reveal the contribution of microsatellite insertions and deletions to the mutational landscape in human cancer.

Yosef E Maruvka
Kent W Mouw
Gad Getz
Article 11 Sept 2017
Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries

Mouse fibroblasts are reprogrammed to induced pluripotent stem cells using single-chain antibodies in place of transcription-factor genes.

Joel W Blanchard
Jia Xie
Kristin K Baldwin

Collection:

Stem cells from development to the clinic
Article 11 Sept 2017
Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments

Draft genome, 994 re-sequenced lines and GWAS for yield-traits provide a resource of genetics and genomics tools for pearl millet researchers and breeders.

Rajeev K Varshney
Chengcheng Shi
Xun Xu
Article Open Access 18 Sept 2017

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Letter

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

An in-droplet immunoassay enables determination of the rate and affinity of secreted antigen-specific antibodies at the single-cell level.

Klaus Eyer
Raphaël C L Doineau
Jean Baudry
Letter 11 Sept 2017
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities

Multiplexed mass spectrometry analysis of breast cancer cell lines uncovers co-regulation of protein abundance that predicts the vulnerabilities of different cancers to drugs.

John D Lapek Jr
Patricia Greninger
Wilhelm Haas
Letter 11 Sept 2017

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Careers and Recruitment

Scientists need data visualization training

Data visualization skills greatly affect research quality and the publications that are vital to an academic career.

Mohamed Elgendi
Careers and Recruitment 11 Oct 2017
People

Careers and Recruitment 11 Oct 2017

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Volume 35 Issue 10, October 2017

Editorial

News

Bioentrepreneur

Correspondence

Commentary

Patents

News & Views

Review Article

Brief Communication

Article

Letter

Careers and Recruitment

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