Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Inducing tolerance one antigen at a time

Nature Biotechnology volume 34, pages 515–517 (2016)Cite this article

Subjects

Autoimmune diseases are reversed in mice using nanoparticles that display disease-associated antigens bound to MHC class II molecules.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Nanoparticles bearing pMHC complexes activate a known immunosuppressive network.

References

  1. Clemente-Casares, X., et al. Nature 530, 434–440 (2016).

    Article  CAS  Google Scholar 

  2. Weiner, H.L., da Cunha, A.P., Quintana, F. & Wu, H. Immunol. Rev. 241, 241–259 (2011).

    Article  CAS  Google Scholar 

  3. Walczak, A., Siger, M., Ciach, A., Szczepanik, M. & Selmaj, K. JAMA Neurol. 70, 1105–1109 (2013).

    Article  Google Scholar 

  4. Fissolo, N., Montalban, X. & Comabella, M. Clin. Immunol. 142, 76–83 (2012).

    Article  CAS  Google Scholar 

  5. Lutterotti, A. et al. Sci. Transl. Med. 5, 188ra75 (2013).

    Article  Google Scholar 

  6. Getts, D.R. et al. Nat. Biotechnol. 30, 1217–1224 (2012).

    Article  CAS  Google Scholar 

  7. Tsai, S. et al. Immunity 32, 568–580 (2010).

    Article  CAS  Google Scholar 

  8. Gregori, S., Goudy, K.S. & Roncarolo, M.G. Front. Immunol. 3, 30 (2012).

    Article  CAS  Google Scholar 

  9. Pot, C. et al. J. Immunol. 183, 797–801 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rafael M. Rezende & Howard L. Weiner are at the Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Rafael M Rezende & Howard L Weiner

Authors
  1. Rafael M Rezende
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Howard L Weiner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Howard L Weiner.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rezende, R., Weiner, H. Inducing tolerance one antigen at a time. Nat Biotechnol 34, 515–517 (2016). https://doi.org/10.1038/nbt.3573

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3573

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing