Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

No longer going to waste

An Erratum to this article was published on 09 August 2016

This article has been updated

Skeletal muscle atrophy offers a huge opportunity for an effective drug. After many failures, industry may be on the verge. Ken Garber reports.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Myostatin signaling limits muscle growth and strength by blocking muscle protein synthesis and triggering muscle protein degradation.

Change history

  • 27 July 2016

    In the version of this article initially published, on p.460, columns 1 and 2, the number following “ACE-” was given as “2454” instead of “2494.” The errors have been corrected in the HTML and PDF versions of the article.

References

  1. Meriggioli, M.N. & Roubenoff, R. Calcif. Tissue Int. 96, 234–242 (2015).

    Article  CAS  Google Scholar 

  2. McPherron, A.C., Lawler, A.M. & Lee, S.J. Nature 387, 83–90 (1997).

    Article  CAS  Google Scholar 

  3. Lee, S.J. et al. Proc. Natl. Acad. Sci. USA 102, 18117–18122 (2005).

    Article  CAS  Google Scholar 

  4. Glasser, C.E. et al. Poster no. 1-72 at the 8th International Conference on Cachexia, Sarcopenia and Muscle Wasting, Paris, December 4–6, 2015.

  5. Amato, A.A. et al. Neurology 83, 2239–2246 (2014).

    Article  CAS  Google Scholar 

  6. Loffredo, F.S. et al. Cell 153, 828–839 (2013).

    Article  CAS  Google Scholar 

  7. Katsimpardi, L. et al. Science 344, 630–634 (2014).

    Article  CAS  Google Scholar 

  8. Sinha, M. et al. Science 344, 649–652 (2014).

    Article  CAS  Google Scholar 

  9. Egerman, M.A. et al. Cell Metab. 22, 164–174 (2015).

    Article  CAS  Google Scholar 

  10. Poggioli, T. et al. Circ. Res. 19, 29–37 (2016).

    Article  Google Scholar 

  11. Dalton, J.T. et al. J. Cachexia Sarcopenia Muscle 2, 153–161 (2011).

    Article  Google Scholar 

  12. Garcia, J.M. et al. Lancet Oncol. 16, 108–116 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Garber, K. No longer going to waste. Nat Biotechnol 34, 458–461 (2016). https://doi.org/10.1038/nbt.3557

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3557

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research