Volume 34 Issue 3, March 2016

Editorial

Breaking out of the bubble

The biotech community has made remarkable progress over the past 20 years. Now it needs to break out of its bubble.

Focus:

Nature Biotechnology 20th Anniversary
Editorial 10 Mar 2016
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News

Immune profiling players shift gear to guide cancer drug development

Michael Eisenstein
News 10 Mar 2016
Drug developers refocus efforts on RAS

Cormac Sheridan
News 10 Mar 2016
Natural killer cells blaze into immuno-oncology

Ken Garber
News 10 Mar 2016
FDA head Califf spurned

News 10 Mar 2016
GM salmon shut out of US

News 10 Mar 2016
GM mosquitoes fire first salvo against Zika virus

Emily Waltz
News 10 Mar 2016
Bial incident raises FAAH suspicions

Eva von Schaper
News 10 Mar 2016
Seed spy pleads guilty

Emily Waltz
News 10 Mar 2016
Sanofi drops MannKind's inhaled insulin

Mark Ratner
News 10 Mar 2016
Around the world in a month

News 10 Mar 2016

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Bioentrepreneur

Aligning needs

The best way for aspiring entrepreneurs to achieve their financing goals is to understand what investors and partners want.

Dennis Ford
William Kohlbrenner

Nature Outlook:

Research commercialization
Bioentrepreneur 10 Mar 2016

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Correspondence

Deciphering the EU clinical trials regulation

Mohamed Abou-El-Enein
Christian K Schneider
Correspondence 10 Mar 2016
A call for industry to embrace green biopharma

Kristi L Budzinski
Stefan G Koenig
Tse-Sung Wu
Correspondence 10 Mar 2016
Marketplace response to GM animal products

Damien Mather
Rasmus Vikan
John Knight
Correspondence 10 Mar 2016

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Commentary

Digital medicine's march on chronic disease

Digital medicine offers the possibility of continuous monitoring, behavior modification and personalized interventions at low cost, potentially easing the burden of chronic disease in cost-constrained healthcare systems.

Joseph C Kvedar
Alexander L Fogel
Daphne Zohar
Commentary 10 Mar 2016

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Feature

Estimating the biotech sector's contribution to the US economy

US biotech sector revenue is estimated to have grown on average >10% each year over the past decade—much faster than the rest of the economy. A more comprehensive assessment of biotech's economic contribution, however, will require improved data collection, classification and analysis.

Robert Carlson

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
20 years of Nature Biotechnology research tools

Authors of some of the most highly cited Nature Biotechnology papers that describe research tools discuss their work and challenges for their fields.

Anna Azvolinsky
Laura DeFrancesco
Sarah Webb

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
20 years of Nature Biotechnology biomedical research

Authors of some of the most highly cited Nature Biotechnology biomedical papers from the past 20 years discuss their work and challenges for their fields.

Anna Azvolinsky
Charles Schmidt
Sarah Webb

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
20 years of Nature Biotechnology bioengineering research

Authors of some of the most highly cited Nature Biotechnology nonbiomedical papers from the past 20 years discuss their work and challenges for their fields.

Laura DeFrancesco
Charles Schmidt
Emily Waltz

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
Voices of biotech

Nature Biotechnology asks a selection of researchers about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications.

Ido Amit
David Baker
Tian Zhang

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
Community crystal gazing

A selection of individuals from the biotech ecosystem give their views on the challenges facing the sector over the coming years.

Anu Acharya
Kate Bingham
Daphne Zohar

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016
When biotech goes bad

A look at 20 years of the dark side of biotech.

John Hodgson

Focus:

Nature Biotechnology 20th Anniversary
Feature 10 Mar 2016

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Patents

The changing life science patent landscape

What have we learned from 20 tumultuous years of patent law in the life sciences? Is patenting likely to be as important for the industry in the future?

Arti K Rai
Jacob S Sherkow

Focus:

Nature Biotechnology 20th Anniversary
Patents 10 Mar 2016

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News & Views

From clinical imaging to implantation of 3D printed tissues

Mechanically stable bone, cartilage and muscle tissues are printed in custom shapes.

E Thomas Pashuck
Molly Stevens
News & Views 10 Mar 2016
Haplotypes drop by drop

Short-read sequencing provides haplotype information when long DNA fragments are barcoded in microfluidic droplets.

Jacob O Kitzman
News & Views 10 Mar 2016
Research Highlights

News & Views 10 Mar 2016
Cas9 loosens its grip on off-target sites

Two new variants of the Cas9 nuclease have minimal activity at off-target DNA sites.

Christopher E Nelson
Charles A Gersbach
News & Views 10 Mar 2016

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Analysis

Fast search of thousands of short-read sequencing experiments

A data indexing method enables fast and computationally efficient searching of short-read sequencing archives.

Brad Solomon
Carl Kingsford
Analysis 08 Feb 2016

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Article

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

A microfluidics approach that links short sequence reads enables haplotype construction and complex variation identification from tiny amounts of input DNA.

Grace X Y Zheng
Billy T Lau
Hanlee P Ji
Article 01 Feb 2016
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

A new bioprinting system produces large tissue constructs with enough structural stability for surgical implantation.

Hyun-Wook Kang
Sang Jin Lee
Anthony Atala
Article 15 Feb 2016
Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

Cortical activity can be monitored for 6 months or longer from within the brain vasculature using an endovascular stent-electrode array.

Thomas J Oxley
Nicholas L Opie
Terence J O'Brien

Collection:

Bioelectronic interfaces
Article 08 Feb 2016

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Letter

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Cas9-mediated gene editing corrects hereditary tyrosinemia in a mouse model.

Hao Yin
Chun-Qing Song
Daniel G Anderson
Letter 01 Feb 2016
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

In vivo delivery of CRISPR-Cas9 corrects mutation in newborn mouse liver.

Yang Yang
Lili Wang
James M Wilson
Letter 01 Feb 2016
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

The efficiency of homology-directed genome editing with CRISPR-Cas9 is boosted through improved design of donor DNA.

Christopher D Richardson
Graham J Ray
Jacob E Corn
Letter 20 Jan 2016
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

In vivo screening of a large combinatorial library of alginates identifies materials that elicit a substantially reduced foreign body response.

Arturo J Vegas
Omid Veiseh
Daniel G Anderson
Letter 25 Jan 2016

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Careers and Recruitment

Towards sustaining a culture of mental health and wellness for trainees in the biosciences

Addressing the mental health of graduate and postdoctoral trainees in the biosciences will substantially benefit the scientific community at large.

Jessica W Tsai
Fanuel Muindi
Careers and Recruitment 10 Mar 2016
People

Careers and Recruitment 10 Mar 2016

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In This Issue

In this issue

In This Issue 10 Mar 2016

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Volume 34 Issue 3, March 2016

Editorial

News

Bioentrepreneur

Correspondence

Commentary

Feature

Patents

News & Views

Analysis

Article

Letter

Careers and Recruitment

In This Issue

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