Volume 33 Issue 5, May 2015

Editorial

Next-generation genome editing

Nature Biotechnology supports recent calls for public engagement concerning the risks and benefits of genome editing in the human germline, particularly given our poor knowledge of what we should change in the human genome.

Editorial 12 May 2015

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News

CRISPR germline editing reverberates through biotech industry

Cormac Sheridan
News 12 May 2015
Startups use short-read data to expand long-read sequencing market

Michael Eisenstein
News 12 May 2015
FDA approves 23andMe gene carrier test

News 12 May 2015
Court sides with Sandoz over Neupogen biosimilar

News 12 May 2015
Human cell assays for new medicines now open access

Asher Mullard
News 12 May 2015
Keytruda UK's first early-access drug

News 12 May 2015
Epigenome drug approved after setback

News 12 May 2015
Biogen's early Alzheimer's data raise hopes, some eyebrows

Mark Ratner
News 12 May 2015
First-in-class HIV drug enters phase 3 trials

Anna Azvolinsky
News 12 May 2015

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Correction

Corrections

Correction 12 May 2015

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News

Lilly pays $50 million for Korean BTK

Allison Proffitt
News 12 May 2015
Around the world in a month

News 12 May 2015

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Data Page

Quality traits reach market

Andrew Marshall
Data Page 12 May 2015
Biotech continues to soar in 1Q15

Walter Yang
Data Page 12 May 2015

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Bioentrepreneur

Research institute partnerships 2014

Brady Huggett
Bioentrepreneur 23 Apr 2014
Startups on the menu: Atreca

Bioentrepreneur 23 Apr 2014

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Correspondence

MutMap accelerates breeding of a salt-tolerant rice cultivar

Hiroki Takagi
Muluneh Tamiru
Ryohei Terauchi
Correspondence 23 Mar 2015
Precision medicine and the FDA's draft guidance on laboratory-developed tests

Thomas J Hwang
Lisa Soleymani Lehmann
Aaron S Kesselheim
Correspondence 12 May 2015
What's behind a 'genetically engineered' label?

Graham Brookes
Henry I Miller
Correspondence 12 May 2015
Transparency in GM food labeling

Peter Melchett
Correspondence 12 May 2015
Nature Biotechnology Responds to Melchett Correspondence

Correspondence 12 May 2015
Oversight of human inheritable genome modification

Rosario Isasi
Bartha M. Knoppers
Correspondence 12 May 2015

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Commentary

Defining digital medicine

Digital medicine is poised to transform biomedical research, clinical practice and the commercial sector. Here we introduce a monthly column from R&D/venture creation firm PureTech tracking digital medicine's emergence.

Eric Elenko
Lindsay Underwood
Daphne Zohar
Commentary 12 May 2015
The digital phenotype

In the coming years, patient phenotypes captured to enhance health and wellness will extend to human interactions with digital technology.

Sachin H Jain
Brian W Powers
John S Brownstein
Commentary 12 May 2015
What Ebola tells us about outbreak diagnostic readiness

Healthcare priorities all too often ignore the importance of diagnostics for disease control and case management. The Ebola epidemic illustrates the folly of this attitude when few therapeutic or prophylactic interventions are available.

Mark D Perkins
Mark Kessel
Commentary 12 May 2015

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Feature

Biotech's wellspring—a survey of the health of the private sector in 2014

Private biotech never had it so good. Although the number of startups formed did not increase dramatically, the sector grew in size and received much more money than in 2013.

Brady Huggett
Feature 12 May 2015
CRISPR germline engineering—the community speaks

Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.

Katrine S Bosley
Michael Botchan
Qi Zhou

Collection:

The Kavli Prize 2018
Feature 12 May 2015

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Patents

A solution to the controversy on plant variety protection in Africa

African countries can establish a plant variety protection system that supports commercial seed systems without negatively affecting smallholder farmers.

Bram De Jonge
Niels P Louwaars
Julian Kinderlerer
Patents 12 May 2015
Recent patent applications in genome editing

Patents 12 May 2015

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News & Views

Putting cells in their place

A combination of single-cell transcriptomics with in situ hybridization information enables single cells to be positioned within their tissue.

Omid R Faridani
Rickard Sandberg
News & Views 12 May 2015
Unraveling the fabric of polyploidy

Draft genome sequences of tetraploid Upland cotton and other polyploids promise insights into genome evolution and cotton fiber biology.

Andrew H Paterson
Jonathan F Wendel
News & Views 12 May 2015
Islet implantation in a pocket

Exploiting the foreign body reaction creates a prevascularized space that accommodates and supports transplanted islets.

Jonathan S Bromberg
News & Views 12 May 2015
Research Highlights

News & Views 12 May 2015

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Analysis

Spatial reconstruction of single-cell gene expression data

RNA-seq data from single cells are mapped to their location in complex tissues using gene expression atlases based on in situ hybridization.

Rahul Satija
Jeffrey A Farrell
Aviv Regev

Collection:

25th Anniversary Collection
Analysis 13 Apr 2015
High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin

Single cells profiled by RNA-seq are rapidly assigned to their location in a complextissue using data in gene expression atlases.

Kaia Achim
Jean-Baptiste Pettit
John C Marioni
Analysis 13 Apr 2015

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Article

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

RNA-guided epigenome editing with Cas9 fused to an acetyltransferase domain activates gene expression through modification of promoters and enhancers.

Isaac B Hilton
Anthony M D'Ippolito
Charles A Gersbach

Collection:

Department of Biomedical Engineering at Duke University
Article 06 Apr 2015
A prevascularized subcutaneous device-less site for islet and cellular transplantation

Diabetes reversal in mice is achieved by transplanting islets into a prevascularized space under the skin.

Andrew R Pepper
Boris Gala-Lopez
A M James Shapiro
Article 20 Apr 2015
Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution

Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, genome rearrangement, gene evolution and cotton fiber biology.

Fuguang Li
Guangyi Fan
Shuxun Yu
Article Open Access 20 Apr 2015
Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement

Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, genome rearrangement, gene evolution and cotton fiber biology.

Tianzhen Zhang
Yan Hu
Z Jeffrey Chen
Article Open Access 20 Apr 2015

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Letter

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

The efficiency of homologous recombination-based Cas9 genome editing is increased by inhibiting non-homologous end joining.

Takeshi Maruyama
Stephanie K Dougan
Hidde L Ploegh
Letter 23 Mar 2015
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

The efficiency of precise CRISPR/Cas9 genome editing is increased by inhibition of the nonhomologous end joining pathway.

Van Trung Chu
Timm Weber
Ralf Kühn
Letter 24 Mar 2015
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

Inhibiting virus cell entry by targeting tight junctions cures HCV infection in mice.

Laurent Mailly
Fei Xiao
Thomas F Baumert
Letter 23 Mar 2015

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Resource

C2H2 zinc finger proteins greatly expand the human regulatory lexicon

Comprehensive analysis of the binding specificities of C2H2 zinc finger proteins reveals their DNA recognition code.

Hamed S Najafabadi
Sanie Mnaimneh
Timothy R Hughes
Resource 18 Feb 2015

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Erratum

Erratum: Modeling the course of amyotrophic lateral sclerosis

Christina Fournier
Jonathan D Glass
Erratum 12 May 2015
Erratum: Selling long life

Christopher Thomas Scott
Laura DeFrancesco
Erratum 12 May 2015

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Corrigendum

Correction: Corrigendum: Taking charge of siRNA delivery

Anastasia Khvorova
Maire F Osborn
Matthew R Hassler
Corrigendum 12 May 2015

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Careers and Recruitment

First-quarter biotech job picture

Michael Francisco
Careers and Recruitment 12 May 2015
People

Careers and Recruitment 12 May 2015

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Volume 33 Issue 5, May 2015

Editorial

News

Correction

News

Data Page

Bioentrepreneur

Correspondence

Commentary

Feature

Patents

News & Views

Analysis

Article

Letter

Resource

Erratum

Corrigendum

Careers and Recruitment

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