Using a ranking of US research institutions based on five years (2010–2014) of total gross licensing revenue reported by the Association of University Technology Managers (AUTM), Nature Biotechnology obtained detailed life science commercialization information for 2014, then re-ranked these major universities by number of licenses/options executed (Table 1). Biomedical research institutes are found in Table 2. The number of licenses executed from this group have jumped considerably (566 for 10 universities in 2013; 1,072 for 11 in 2014), life science startups also grew (93 for 10 schools in 2013; 136 for 11 in 2014). Life sciences remain the driving force behind startup creation for this group (Fig. 1), with New York University sitting atop our list of license income earners (Fig. 2).