Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Crystal structure of Staphylococcus aureus Cas9

Nishimasu, H. et al. Cell 162, 1113–1126 (2015)

High-throughput pairing of T cell receptor α and β sequences

Howie, B. et al. Sci. Transl. Med. 7, 131 (2015)

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

Prost, S. et al. Nature 525, 380–383 (2015)

Complete biosynthesis of opioids in yeast

Galanie, S. et al. Science 349, 1095–1100 (2015)

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

Yang, J. et al. Nat. Genet. doi: 10.1038/ng.3390 (31 August 2015)