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Editorial

Bring out your dead p1

doi:10.1038/nbt.3123

Despite recent progress, only a fraction of the drug industry's shelved compounds are shared with the research community. Could online collaborative research offer a solution?


IL-17–targeting biologics aim to become standard of care in psoriasis pp3 - 4

Mark Ratner

doi:10.1038/nbt0115-3



PCORI takes up HCV treatment options p4

doi:10.1038/nbt0115-4b


Amgen's angiopoietin blocker fails in ovarian cancer pp5 - 6

Cormac Sheridan

doi:10.1038/nbt0115-5


Clinuvel's tanning agent nears approval for porphyria p7

Asher Mullard

doi:10.1038/nbt0115-7


Foundation receives $3.3-billion windfall for Kalydeco pp8 - 9

Melanie Senior

doi:10.1038/nbt0115-8




BMS options Galecto buy p9

doi:10.1038/nbt0115-9c


IBM's Watson Group signs up genomics partners pp10 - 11

Mark Ratner

doi:10.1038/nbt0115-10


How frothy is this IPO window? p11

Brian Orelli

doi:10.1038/nbt0115-11


USDA approves next-generation GM potato pp12 - 13

Emily Waltz

doi:10.1038/nbt0115-12


Around the world in a month p13

doi:10.1038/nbt0115-13


News Feature

Social storm pp14 - 17

Virginia Hughes

doi:10.1038/nbt.3106

The drug industry is struggling to find ways of engaging with consumers on social media. Failure to adapt may bring substantial opportunity costs, argues Virginia Hughes.


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Bioentrepreneur

Datapage

Innovative startups in 2014 p18

Brady Huggett

doi:10.1038/nbt.3113


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Opinion and Comment

Correspondence

Biosimilars or semi-similars? pp19 - 20

Huub Schellekens & Ellen Moors

doi:10.1038/nbt.3083


Outcubation—where incubation meets outsourcing pp20 - 21

Ulrich A K Betz & Christian A Tidona

doi:10.1038/nbt.3112


PeptideShaker enables reanalysis of MS-derived proteomics data sets pp22 - 24

Marc Vaudel, Julia M Burkhart, René P Zahedi, Eystein Oveland, Frode S Berven, Albert Sickmann, Lennart Martens & Harald Barsnes

doi:10.1038/nbt.3109


Intellectual property issues and synthetic biology standards pp24 - 25

Jorge L Contreras, Arti K Rai & Andrew W Torrance

doi:10.1038/nbt.3107



Status and market potential of transgenic biofortified crops pp25 - 29

Hans De Steur, Dieter Blancquaert, Simon Strobbe, Willy Lambert, Xavier Gellynck & Dominique Van Der Straeten

doi:10.1038/nbt.3110


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Features

Selling long life pp31 - 40

Christopher Thomas Scott & Laura DeFrancesco

doi:10.1038/nbt.3108

A new generation of commercial entities is beginning to explore opportunities for new types of interventions and services in a graying world.


Patents

The impact of European embryonic stem cell patent decisions on research strategies pp41 - 43

Aurélie Mahalatchimy, Emmanuelle Rial-Sebbag, Anne-Marie Duguet, Florence Taboulet & Anne Cambon-Thomsen

doi:10.1038/nbt.3105

Recent restrictions on the patentability of human embryonic stem cell inventions in Europe necessitate a shift in R&D strategies.


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News and Views

Cancer immunotherapy meets biomaterials pp44 - 45

Jeffrey S Weber & James J Mulé

doi:10.1038/nbt.3119

Engineered biomaterials boost the efficacy of cancer vaccines and adoptive T cell therapies.

See also: Research by Kim et al. | Research by Stephan et al.


Modeling the course of amyotrophic lateral sclerosis pp45 - 47

Christina Fournier & Jonathan D Glass

doi:10.1038/nbt.3118

Large-scale computational analysis of patient data leads to better models of disease progression.

See also: Computational Biology by Küffner et al.


Systematic discovery of probiotics pp47 - 49

Samuel C Forster & Trevor D Lawley

doi:10.1038/nbt.3111

Systems-level modeling of the gut microbiota uncovers a candidate bacteriotherapy for Clostridium difficile.


Research Highlights p48

doi:10.1038/nbt.3120


DREAMing of benchmarks pp49 - 50

Irene Jarchum & Susan Jones

doi:10.1038/nbt.3115


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Computational Biology

Analysis

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression pp51 - 57

Robert Küffner, Neta Zach, Raquel Norel, Johann Hawe, David Schoenfeld, Liuxia Wang, Guang Li, Lilly Fang, Lester Mackey, Orla Hardiman, Merit Cudkowicz, Alexander Sherman, Gokhan Ertaylan, Moritz Grosse-Wentrup, Torsten Hothorn, Jules van Ligtenberg, Jakob H Macke, Timm Meyer, Bernhard Schölkopf, Linh Tran, Rubio Vaughan, Gustavo Stolovitzky & Melanie L Leitner

doi:10.1038/nbt.3051

An open competition to predict the progression of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) disease from the largest database of ALS clinical trial data yields potential new biomarkers and algorithms that outperform human clinicians.

See also: News and Views by Fournier & Glass


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Research

Analysis

A comparison of non-integrating reprogramming methods pp58 - 63

Thorsten M Schlaeger, Laurence Daheron, Thomas R Brickler, Samuel Entwisle, Karrie Chan, Amelia Cianci, Alexander DeVine, Andrew Ettenger, Kelly Fitzgerald, Michelle Godfrey, Dipti Gupta, Jade McPherson, Prerana Malwadkar, Manav Gupta, Blair Bell, Akiko Doi, Namyoung Jung, Xin Li, Maureen S Lynes, Emily Brookes, Anne B C Cherry, Didem Demirbas, Alexander M Tsankov, Leonard I Zon, Lee L Rubin, Andrew P Feinberg, Alexander Meissner, Chad A Cowan & George Q Daley

doi:10.1038/nbt.3070

A comparison of different ways of generating induced pluripotent stem cells helps researchers choose the most appropriate method for particular applications.


Articles

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy pp64 - 72

Jaeyun Kim, Weiwei Aileen Li, Youngjin Choi, Sarah A Lewin, Catia S Verbeke, Glenn Dranoff & David J Mooney

doi:10.1038/nbt.3071

Vaccine efficiency is enhanced by mesoporous silica rods that spontaneously form a 3D microenvironment for immune cells.

See also: News and Views by Weber & Mulé


Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo pp73 - 80

John A Zuris, David B Thompson, Yilai Shu, John P Guilinger, Jeffrey L Bessen, Johnny H Hu, Morgan L Maeder, J Keith Joung, Zheng-Yi Chen & David R Liu

doi:10.1038/nbt.3081

Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro.


Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice pp81 - 88

Brian D Henry, Daniel R Neill, Katrin Anne Becker, Suzanna Gore, Laura Bricio-Moreno, Regan Ziobro, Michael J Edwards, Kathrin Mühlemann, Jörg Steinmann, Burkhard Kleuser, Lukasz Japtok, Miriam Luginbühl, Heidi Wolfmeier, André Scherag, Erich Gulbins, Aras Kadioglu, Annette Draeger & Eduard B Babiychuk

doi:10.1038/nbt.3037

Decoy liposomes that bind and sequester bacterial exotoxins can be used to combat septicemia and infection.


Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes pp89 - 96

Yves Maury, Julien Côme, Rebecca A Piskorowski, Nouzha Salah-Mohellibi, Vivien Chevaleyre, Marc Peschanski, Cécile Martinat & Stéphane Nedelec

doi:10.1038/nbt.3049

Combinatorial screening of developmental factors improves directed differentiation of human pluripotent stem cells into neuronal subtypes.


Letters

Biopolymer implants enhance the efficacy of adoptive T-cell therapy pp97 - 101

Sirkka B Stephan, Alexandria M Taber, Ilona Jileaeva, Ericka P Pegues, Charles L Sentman & Matthias T Stephan

doi:10.1038/nbt.3104

Delivery of T cells using an alginate polymer–based implant enhances the efficacy of cancer immunotherapy.

See also: Research by Stephan et al.


In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9 pp102 - 106

Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li, John Trombetta, Mriganka Sur & Feng Zhang

doi:10.1038/nbt.3055

CRISPR-Cas9 can be used to edit both single and multiple genes in postmitotic neurons in adult mice enabling rapid assessment of gene functions in the brain.


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Careers and Recruitment

Life sciences workforce trends evolve with the industry pp107 - 109

Kathy L Nugent & Lori Lindburg

doi:10.1038/nbt.3116

As the biotech industry grows and shifts within an increasingly global economy, so does its need for talent that spans discovery through commercialization.


People

People p110

doi:10.1038/nbt.3125


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