Nature Biotechnology

Volume 32 Issue 2, February 2014

A more detailed and comprehensive analysis of the immune system will reveal basic and translational insights and may lead to development of new therapeutic strategies. In this months joint Focus with Nature Immunology, featured articles describe the new technologies and computational approaches that enable this sort of high-dimensional characterization of components of the immune system. www.nature.com/focus/ high_dimensional_immune_analysis Artwork by Lewis Long.

Volume 32 Issue 2

Editorial

Search and development

In an effort to rein in costs and galvanize its discovery effort, Merck is following the industry vogue for externalizing early-stage R&D. Is it going to cast its net far and wide enough?

Editorial 07 Feb 2014

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News

Milestone approval lifts Illumina's NGS from research into clinic

Cormac Sheridan
News 07 Feb 2014
Investor stampede for CARs

Laura DeFrancesco
News 07 Feb 2014
Imbruvica—next big drug in B-cell cancer—approved by FDA

Malini Guha
News 07 Feb 2014
Shire shifts towards rare diseases

Nuala Moran
News 07 Feb 2014
Illumina claims $1,000 genome win

Cormac Sheridan
News 07 Feb 2014
PARP inhibitors' revival

Asher Mullard
News 07 Feb 2014
Celgene's multibillion spree on Oncomed/NYC

Brian Orelli
News 07 Feb 2014
Master Protocol for squamous cell lung cancer readies for launch

Jeffrey L Fox
News 07 Feb 2014
It's official: biologics are pharma's darlings

Emily Waltz
News 07 Feb 2014
Boston quartet revamps biopsies

Allison Proffitt
News 07 Feb 2014
Setback for JAK2 inhibitors

Mark Ratner
News 07 Feb 2014
UK boosts discovery tools

Gunjan Sinha
News 07 Feb 2014
Around the world in a month

News 09 Jan 2014

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News Feature

Fresh from the biotech pipeline—2013

Despite an overall dip in FDA approvals of new chemical and biologic entities, 2013 wasn't a bad year for innovator drugs. Jim Kling reports.

Jim Kling
News Feature 07 Feb 2014

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Data Page

Drug pipeline 4Q13

Laura DeFrancesco
Data Page 07 Feb 2014
2013—biotech back in the saddle

Walter Yang
Data Page 07 Feb 2014
Innovative startups 2013

Brady Huggett
Data Page 07 Feb 2014

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Correspondence

Biologic product identification and US pharmacovigilance in the biosimilars era

Thomas Felix
Torbjörn T Johansson
Andrew R Fox
Correspondence 07 Feb 2014
A divided INN crowd

William W Chin
Correspondence 07 Feb 2014
A divided INN crowd

Geoff Eich
Correspondence 07 Feb 2014
A divided INN crowd

Jim Greenwood
Correspondence 07 Feb 2014
A divided INN crowd

Huub Schellekens
Correspondence 07 Feb 2014
Nature Biotechnology responds

Correspondence 07 Feb 2014

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Patents

Pharmaceutical and biotech product patents in India: doldrums or blissfulness?

Confusion reigns over pharmaceutical and biotech-related patents in India owing to uncertain application of patent law and pressure from generics.

Pritom Chowdhury
Siraj A Khan
Jagadish Mahanta
Patents 07 Feb 2014
Recent patent applications in immunostaining

Patents 07 Feb 2014

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News & Views

Bispecific antibodies with native chain structure

Two new methods overcome a major hurdle that blocked easy and efficient design and expression of human bispecific antibodies.

Romain Rouet
Daniel Christ
News & Views 07 Feb 2014
Research Highlights

News & Views 07 Feb 2014
PIQ-ing into chromatin architecture

Decrypting the logic of gene regulation is aided by a breakthrough method for analyzing chromatin-accessibility data.

Sebastian Rieck
Christopher Wright
News & Views 07 Feb 2014
Of snowflakes and natural killer cell subsets

Mass cytometric analysis reveals a remarkable and unanticipated degree of phenotypic heterogeneity among human peripheral blood natural killer cells.

Lewis L Lanier
News & Views 07 Feb 2014
A one-two punch knocks out biofilms

Irene Jarchum
News & Views 07 Feb 2014

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Editorial

New dimensions in immunology

Emerging technologies are broadening our understanding of the human immune system, but capitalizing on their application will likely require philosophical and practical changes to the way research is done.

Editorial 19 Jan 2014

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Correspondence

Computational resources for high-dimensional immune analysis from the Human Immunology Project Consortium

Vladimir Brusic
Raphael Gottardo
Alkis Togias
Correspondence 19 Jan 2014

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Review Article

Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

Davis and Newell explain how cytometry, and single-cell and sequencing methodologies can be used to characterize human T-cell responses in health and disease.

Evan W Newell
Mark M Davis
Review Article 19 Jan 2014
The promise and challenge of high-throughput sequencing of the antibody repertoire

Georgiou and colleagues discuss rapidly evolving methods for high-throughput sequencing of the antibody repertoire, and how the resulting data may be applied to answer basic and translational research questions.

George Georgiou
Gregory C Ippolito
Stephen R Quake
Review Article 19 Jan 2014

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Analysis

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

A new algorithm learns features of chromatin profiles left by transcription factors, shedding light on when DNA sequence motifs are bound.

Richard I Sherwood
Tatsunori Hashimoto
David K Gifford
Analysis 19 Jan 2014

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Brief Communication

Single-molecule site-specific detection of protein phosphorylation with a nanopore

A protein nanopore can distinguish model proteins phosphorylated at adjacent sites.

Christian B Rosen
David Rodriguez-Larrea
Hagan Bayley
Brief Communication 19 Jan 2014

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Article

Smac mimetics and innate immune stimuli synergize to promote tumor death

Synergistic cancer therapies SMAC mimetic compounds synergize with oncolytic viruses and other innate immune stimuli to promote tumor cell death.

Shawn T Beug
Vera A Tang
Robert G Korneluk
Article 26 Jan 2014
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody heavy and light chains with orthogonal interfaces.

Steven M Lewis
Xiufeng Wu
Stephen J Demarest
Article 26 Jan 2014

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Careers and Recruitment

Fourth-quarter biotech job picture

Michael Francisco
Careers and Recruitment 07 Feb 2014
People

Careers and Recruitment 07 Feb 2014

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In This Issue

In this issue

In This Issue 07 Feb 2014

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Focus

High-dimensional analysis of the immune system

New technologies enable analysis of the extraordinarily diverse and polymorphic components of the immune system–especially the human immune system–at a level of unprecedented detail. Reviews and a Commentary specially commissioned by Nature Biotechnology and Nature Immunology discuss these new methodologies, and how they may be applied to track immune status in health and disease, as well as to reveal new basic immunological insight. A Correspondence describing an initiative to design tools and resources to facilitate these high-dimensional analyses is also included.

Focus 01 Feb 2014

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