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Artists impression of an SATE - modified siRNA in the process of being deprotected by cellular thioesterases after entering the cytosol (p 1256). Credit: Peter Allen, UCSB College of Engineering
Recent developments in the prosecution of the CRISPR-Cas9 patent in Europe highlight the differences between the intellectual property regimes of Europe and the United States.
A community of researchers report the lessons learned from applying 44 algorithms to predict drug sensitivity in cancer cell lines using genomic, epigenetic and proteomic datasets
Methylase-assisted bisulfite sequencing allows to determine the genomic locations of the cytosine demethylation intermediates 5-formylcytosine and 5-carboxylcytosine at base pair resolution.
Analysis of the genome editing activity of more than 1800 sgRNAs in mouse and human cells yields rules to facilitate design of highly active RNA guides for Cas-9 genome editing.
