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Cracking the code of human T-cell immunity

Combinatorial tetramer staining coupled with mass cytometry allows simultaneous detection of T cells specific for a wide array of peptide epitopes.

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Figure 1: Overview of peptide-MHC tetramer multiplexing strategy with metal barcodes.

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Correspondence to Kai W Wucherpfennig.

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Harvey, C., Wucherpfennig, K. Cracking the code of human T-cell immunity. Nat Biotechnol 31, 609–610 (2013). https://doi.org/10.1038/nbt.2626

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