Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Deterministic direct reprogramming of somatic cells to pluripotency

Rais, Y. et al. Nature 502, 65–70 (2013)

Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development

Imamovic, L. & Sommer, O.A.M. Sci. Transl. Med. 5, 204ra132 (2013)

Microbial production of short-chain alkanes

Choi, Y. J. & Lee, S.Y. Nature doi:10.1038/nature12536 (29 September 2013)

Clinical whole-exome sequencing for the diagnosis of Mendelian disorders

Yang, Y. et al. NEJM doi:10.1056/NEJMoa1306555 (2 October 2013)

Presentation of large DNA molecules for analysis as nanoconfined dumbbells

Kounovsky-Shafer, K.L. Macromolecules doi:10.1021/ma400926h (7 October 2013)