Table of contents


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Editorial

In need of an upgrade p857

doi:10.1038/nbt.2717

Improving the integration of computational analysis into biology will require better documentation, validation and accessibility of software associated with papers.


Amgen swallows Onyx whole pp859 - 860

Malini Guha

doi:10.1038/nbt1013-859


Courts defer ruling on science p860

Jeffrey L Fox

doi:10.1038/nbt1013-860


China clampdown on GSK linked to drug costs p861

Hepeng Jia

doi:10.1038/nbt1013-861


First mass spectrometry diagnostic approved in US p862

Jennifer Rohn

doi:10.1038/nbt1013-862a


Scripps boosts research coffers by selling reagents to Sigma-Aldrich pp862 - 864

Mark Ratner

doi:10.1038/nbt1013-862b


Elan's Irish tax allure p864

Emily Waltz

doi:10.1038/nbt1013-864


Neurodevice startups target peripheral nervous system pp865 - 866

Michael Eisenstein

doi:10.1038/nbt1013-865


Korea's 9 billion injection p866

Allison Proffitt

doi:10.1038/nbt1013-866


Mars collaborates to sequence Africa's neglected food crops p867

Jeffrey L Fox

doi:10.1038/nbt1013-867a


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Corrections

Correction p867

doi:10.1038/nbt1013-867b


Correction p867

doi:10.1038/nbt1013-867c


From the bottom of a DNA cocktail glass p868

Nuala Moran

doi:10.1038/nbt1013-868


India's onslaught on drug patents continues p869

Lisa Melton

doi:10.1038/nbt1013-869a


Around the world in a month p869

doi:10.1038/nbt1013-869b


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News Feature

Big oil turns on biofuels pp870 - 873

Cormac Sheridan

doi:10.1038/nbt.2704

Despite government incentives and mandates, second-generation biofuels are proving tough to bring to market. Cormac Sheridan investigates.


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Bioentrepreneur

Data Page

Top US universities, institutes for life sciences in 2012 p874

Brady Huggett

doi:10.1038/nbt.2719


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Opinion and Comment

Correspondence

What is the point of large-scale collections of human induced pluripotent stem cells? pp875 - 877

Ruth McKernan & Fiona M Watt

doi:10.1038/nbt.2710


A proposal to use gamete cycling in vitro to improve crops and livestock pp877 - 880

Seth C Murray, Philip Eckhoff, Lowell Wood & Andrew H Paterson

doi:10.1038/nbt.2707


The regulatory landscape for actively personalized cancer immunotherapies pp880 - 882

Cedrik M Britten, Harpreet Singh-Jasuja, Bruno Flamion, Axel Hoos, Christoph Huber, Karl-Josef Kallen, Samir N Khleif, Sebastian Kreiter, Michaela Nielsen, Hans-Georg Rammensee, Ugur Sahin, Thomas Hinz & Ulrich Kalinke

doi:10.1038/nbt.2708


The value of non-human primates in the development of monoclonal antibodies pp882 - 883

P J K van Meer, M Kooijman, J W van der Laan, E H M Moors & H Schellekens

doi:10.1038/nbt.2709


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Features

Patents

DREAMing of a patent-free human genome for clinical sequencing pp884 - 887

Kevin J McKernan, Jessica Spangler, Yvonne Helbert, Lei Zhang & Vasisht Tadigotla

doi:10.1038/nbt.2703

Can methylation be the key to challenging the interpretation of existing gene patent claims? And can a novel PCR method be used to enable the sequencing of hundreds of genes?



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News and Views

Phospho-specific antibodies by design pp889 - 891

Oda Stoevesandt & Michael J Taussig

doi:10.1038/nbt.2712

Antibodies specific to phosphorylated peptides are readily generated through structure-based engineering and in vitro selection.

See also: Research by Koerber et al.


Modified RNA kick-starts cardiac repair pp891 - 892

Seppo Ylä-Herttuala & Einari Aavik

doi:10.1038/nbt.2716

The survival of mice after experimental heart attack is greatly improved by a pulse of RNA therapy.

See also: Research by Zangi et al.


Differences that matter in cancer genomics pp892 - 893

Li Ding & Michael C Wendl

doi:10.1038/nbt.2715

Correcting for mutational heterogeneity within and between tumor samples improves cancer genome analyses.


Research Highlights p893

doi:10.1038/nbt.2718


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Computational Biology

Feature

The anatomy of successful computational biology software pp894 - 897

Stephen Altschul, Barry Demchak, Richard Durbin, Robert Gentleman, Martin Krzywinski, Heng Li, Anton Nekrutenko, James Robinson, Wayne Rasband, James Taylor & Cole Trapnell

doi:10.1038/nbt.2721

Creators of software widely used in computational biology discuss the factors that contributed to their success


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Research

Articles

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction pp898 - 907

Lior Zangi, Kathy O Lui, Alexander von Gise, Qing Ma, Wataru Ebina, Leon M Ptaszek, Daniela Später, Huansheng Xu, Mohammadsharif Tabebordbar, Rostic Gorbatov, Brena Sena, Matthias Nahrendorf, David M Briscoe, Ronald A Li, Amy J Wagers, Derrick J Rossi, William T Pu & Kenneth R Chien

doi:10.1038/nbt.2682

Pulse-like expression of VEGF-A from modified RNA extends survival in a mouse model of myocardial infarction.

See also: News and Views by Ylä-Herttuala & Aavik


Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science pp908 - 915

Paul A Guerette, Shawn Hoon, Yiqi Seow, Manfred Raida, Admir Masic, Fong T Wong, Vincent H B Ho, Kiat Whye Kong, Melik C Demirel, Abdon Pena-Francesch, Shahrouz Amini, Gavin Z Tay, Dawei Ding & Ali Miserez

doi:10.1038/nbt.2671

The engineering of biomimetic materials is accelerated by combining high-throughput RNA sequencing and proteomics.


Nature-inspired design of motif-specific antibody scaffolds pp916 - 921

James T Koerber, Nathan D Thomsen, Brett T Hannigan, William F Degrado & James A Wells

doi:10.1038/nbt.2672

Engineering motif-specific 'hot spots' into an antibody scaffold yields antibodies with high affinity to targets containing phosphoserine, phosphothreonine or phosphotyrosine.

See also: News and Views by Stoevesandt & Taussig


Identifying producers of antibacterial compounds by screening for antibiotic resistance pp922 - 927

Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King, Ricardo Medina & Gerard D Wright

doi:10.1038/nbt.2685

Selecting for microorganisms resistant to known antibiotics enables discovery of strains that produce structurally related compounds.


Letters

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy pp928 - 933

Maria Themeli, Christopher C Kloss, Giovanni Ciriello, Victor D Fedorov, Fabiana Perna, Mithat Gonen & Michel Sadelain

doi:10.1038/nbt.2678

T cells generated from human iPSCs engineered to express a chimeric antigen receptor display innate lymphoid properties and inhibit tumor growth in mice.


Conditional targeted genome editing using somatically expressed TALENs in C. elegans pp934 - 937

Ze Cheng, Peishan Yi, Xiangming Wang, Yongping Chai, Guoxin Feng, Yihong Yang, Xing Liang, Zhiwen Zhu, Wei Li & Guangshuo Ou

doi:10.1038/nbt.2674

TALENs expressed in somatic cells under the control of tissue-specific or inducible promoters generate conditional knockouts in C. elegans.


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Careers and Recruitment

The missing piece to changing the university culture pp938 - 941

Maximiliaan Schillebeeckx, Brett Maricque & Cory Lewis

doi:10.1038/nbt.2706

A new type of initiative is empowering graduate students and postdocs to reshape their academic training, providing another avenue to express their passion for research.


People

People p942

doi:10.1038/nbt.2723


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