Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Modified RNA kick-starts cardiac repair

Nature Biotechnology volume 31, pages 891–892 (2013)Cite this article

Subjects

The survival of mice after experimental heart attack is greatly improved by a pulse of RNA therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Emulsified modRNA injected in infarcted mouse hearts induces shorter-term expression of VEGF-A compared with expression from a DNA plasmid.

References

  1. Ylä-Herttuala, S., Rissanen, T.T., Vajanto, I. & Hartikainen, J. J. Am. Coll. Cardiol. 49, 1015–1026 (2007).

    Article  Google Scholar 

  2. Zangi, L. et al. Nat. Biotechnol. 31, 898–907 (2013).

    Article  CAS  Google Scholar 

  3. Mandel, L.R. & Porec, E. Biochemistry 2, 555–560 (1963).

    Article  CAS  Google Scholar 

  4. Cantara, W.A. et al. Nucleic Acids Res. 39, D195–D201 (2011).

    Article  CAS  Google Scholar 

  5. Jia, G., Fu, Y. & He, C. Trends Genet. 29, 108–115 (2013).

    Article  CAS  Google Scholar 

  6. Dor, Y. et al. EMBO J. 21, 1939–1947 (2002).

    Article  CAS  Google Scholar 

  7. Karvinen, H. et al. Gene Ther. 18, 1166–1172 (2011).

    Article  CAS  Google Scholar 

  8. Liu, Y. et al. J. Clin. Invest. 122, 3101–3113 (2012).

    Article  CAS  Google Scholar 

  9. Dragneva, G., Korpisalo, P. & Ylä-Herttuala, S. Dis. Model. Mech. 6, 312–322 (2013).

    Article  CAS  Google Scholar 

  10. Lähteenvuo, J.E. et al. Circulation 119, 845–856 (2009)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Seppo Ylä-Herttuala and Einari Aavik are at the A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.,

    Seppo Ylä-Herttuala & Einari Aavik

Authors
  1. Seppo Ylä-Herttuala
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Einari Aavik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Seppo Ylä-Herttuala.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ylä-Herttuala, S., Aavik, E. Modified RNA kick-starts cardiac repair. Nat Biotechnol 31, 891–892 (2013). https://doi.org/10.1038/nbt.2716

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2716

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research