Volume 31 Issue 10, October 2013

Close-up of suckers and teeth rings on the tentacles of a Humboldt squid (Dosidicus gigas). Guerette et al. use RNA-seq to rapidly identify proteins that synthesize or constitute biomaterials, including promising silklike proteins from squid sucker ring teeth (p 908). Credit: Louise Murray/ Visuals Unlimited/Corbis

Editorial

In need of an upgrade

Improving the integration of computational analysis into biology will require better documentation, validation and accessibility of software associated with papers.

Editorial 08 Oct 2013

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News

Amgen swallows Onyx whole

Malini Guha
News 08 Oct 2013
Courts defer ruling on science

Jeffrey L Fox
News 08 Oct 2013
China clampdown on GSK linked to drug costs

Hepeng Jia
News 08 Oct 2013
First mass spectrometry diagnostic approved in US

Jennifer Rohn
News 08 Oct 2013
Scripps boosts research coffers by selling reagents to Sigma-Aldrich

Mark Ratner
News 08 Oct 2013
Elan's Irish tax allure

Emily Waltz
News 08 Oct 2013
Neurodevice startups target peripheral nervous system

Michael Eisenstein
News 08 Oct 2013
Korea's 9 billion injection

Allison Proffitt
News 08 Oct 2013
Mars collaborates to sequence Africa's neglected food crops

Jeffrey L Fox
News 08 Oct 2013

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Correction

Correction

Correction 08 Oct 2013
Correction

Correction 08 Oct 2013

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News

From the bottom of a DNA cocktail glass

Nuala Moran
News 08 Oct 2013
India's onslaught on drug patents continues

Lisa Melton
News 08 Oct 2013
Around the world in a month

News 08 Oct 2013

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News Feature

Big oil turns on biofuels

Despite government incentives and mandates, second-generation biofuels are proving tough to bring to market. Cormac Sheridan investigates.

Cormac Sheridan
News Feature 08 Oct 2013

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Bioentrepreneur

Top US universities, institutes for life sciences in 2012

Brady Huggett
Bioentrepreneur 26 Sept 2013

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Correspondence

What is the point of large-scale collections of human induced pluripotent stem cells?

Ruth McKernan
Fiona M Watt
Correspondence 08 Oct 2013
A proposal to use gamete cycling in vitro to improve crops and livestock

Seth C Murray
Philip Eckhoff
Andrew H Paterson
Correspondence 08 Oct 2013
The regulatory landscape for actively personalized cancer immunotherapies

Cedrik M Britten
Harpreet Singh-Jasuja
Ulrich Kalinke
Correspondence 08 Oct 2013
The value of non-human primates in the development of monoclonal antibodies

P J K van Meer
M Kooijman
H Schellekens
Correspondence 08 Oct 2013

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Patents

DREAMing of a patent-free human genome for clinical sequencing

Can methylation be the key to challenging the interpretation of existing gene patent claims? And can a novel PCR method be used to enable the sequencing of hundreds of genes?

Kevin J McKernan
Jessica Spangler
Vasisht Tadigotla
Patents 08 Oct 2013
Recent patent applications in DNA sequencing

Patents 08 Oct 2013

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News & Views

Phospho-specific antibodies by design

Antibodies specific to phosphorylated peptides are readily generated through structure-based engineering and in vitro selection.

Oda Stoevesandt
Michael J Taussig
News & Views 08 Oct 2013
Modified RNA kick-starts cardiac repair

The survival of mice after experimental heart attack is greatly improved by a pulse of RNA therapy.

Seppo Ylä-Herttuala
Einari Aavik
News & Views 08 Oct 2013
Differences that matter in cancer genomics

Correcting for mutational heterogeneity within and between tumor samples improves cancer genome analyses.

Li Ding
Michael C Wendl
News & Views 08 Oct 2013
Research Highlights

News & Views 08 Oct 2013

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Feature

The anatomy of successful computational biology software

Creators of software widely used in computational biology discuss the factors that contributed to their success

Stephen Altschul
Barry Demchak
Cole Trapnell
Feature 08 Oct 2013

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Article

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Pulse-like expression of VEGF-A from modified RNA extends survival in a mouse model of myocardial infarction.

Lior Zangi
Kathy O Lui
Kenneth R Chien
Article 08 Sept 2013
Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science

The engineering of biomimetic materials is accelerated by combining high-throughput RNA sequencing and proteomics.

Paul A Guerette
Shawn Hoon
Ali Miserez
Article 08 Sept 2013
Nature-inspired design of motif-specific antibody scaffolds

Engineering motif-specific 'hot spots' into an antibody scaffold yields antibodies with high affinity to targets containing phosphoserine, phosphothreonine or phosphotyrosine.

James T Koerber
Nathan D Thomsen
James A Wells
Article 18 Aug 2013
Identifying producers of antibacterial compounds by screening for antibiotic resistance

Selecting for microorganisms resistant to known antibiotics enables discovery of strains that produce structurally related compounds.

Maulik N Thaker
Wenliang Wang
Gerard D Wright
Article 22 Sept 2013

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Letter

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

T cells generated from human iPSCs engineered to express a chimeric antigen receptor display innate lymphoid properties and inhibit tumor growth in mice.

Maria Themeli
Christopher C Kloss
Michel Sadelain
Letter 11 Aug 2013
Conditional targeted genome editing using somatically expressed TALENs in C. elegans

TALENs expressed in somatic cells under the control of tissue-specific or inducible promoters generate conditional knockouts in C. elegans.

Ze Cheng
Peishan Yi
Guangshuo Ou
Letter 18 Aug 2013

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Careers and Recruitment

The missing piece to changing the university culture

A new type of initiative is empowering graduate students and postdocs to reshape their academic training, providing another avenue to express their passion for research.

Maximiliaan Schillebeeckx
Brett Maricque
Cory Lewis
Careers and Recruitment 08 Oct 2013
People

Careers and Recruitment 08 Oct 2013

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Volume 31 Issue 10, October 2013

Editorial

News

Correction

News

News Feature

Bioentrepreneur

Correspondence

Patents

News & Views

Feature

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Letter

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