Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Silicon dreams of cells into symbols

Diverse mathematical models combine to create a comprehensive whole-cell computational model of a human pathogen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Whole-cell simulation of M. genitalium.

References

  1. Karr, J.R. et al. Cell 150, 389–401 (2012).

    Article  CAS  Google Scholar 

  2. Tomita, M. Trends Biotechnol. 19, 205–210 (2001).

    Article  CAS  Google Scholar 

  3. Ishii, N., Robert, M., Nakayama, Y., Kanai, A. & Tomita, M. J. Biotechnol. 113, 281–294 (2004).

    Article  CAS  Google Scholar 

  4. Guyton, A.C., Coleman, T.G. & Granger, H.J. Annu. Rev. Physiol. 34, 13–44 (1972).

    Article  CAS  Google Scholar 

  5. Noble, D. Physiology (Bethesda) 19, 191–197 (2004).

    CAS  Google Scholar 

  6. Shoda, L. et al. Clin. Exp. Immunol. 161, 250–267 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Edwards, J.S., Covert, M. & Palsson, B.O. Environ. Microbiol. 4, 133–140 (2002).

    Article  Google Scholar 

  8. Rosen, R. Life Itself: a Comprehensive Enquiry into the Nature, Origin and Fabrication of Life. Complexity in Ecological Systems (Columbia University Press, 2005).

    Google Scholar 

  9. Letelier, J.-C. & Soto-Andrade, J. J. Theor. Biol. 238, 949–961 (2006).

    Article  Google Scholar 

  10. Gunawardena, J. Mol. Biol. Cell 23, 517–519 (2012).

    Article  CAS  Google Scholar 

  11. van Noort, V. et al. Mol. Syst. Biol. 8, 571 (2012).

    Article  Google Scholar 

  12. Yus, E. et al. Science 326, 1263–1268 (2009).

    Article  CAS  Google Scholar 

  13. Güell, M. et al. Science 326, 1268–1271 (2009).

    Article  Google Scholar 

  14. Kühner, S. et al. Science 326, 1235–1240 (2009).

    Article  Google Scholar 

  15. Dror, R.O., Dirks, R.M., Grossman, J.P., Xu, H. & Shaw, D.E. Annu. Rev. Biophys. 41, 429–452 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeremy Gunawardena.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gunawardena, J. Silicon dreams of cells into symbols. Nat Biotechnol 30, 838–840 (2012). https://doi.org/10.1038/nbt.2358

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2358

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research