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Volume 30 Issue 7, July 2012

A field emission scanning electron microscopy image of a primary breast cancer cell beginning to invade the surrounding extracellular matrix by extending filopodia. This issue includes a focus on cancer technologies. Credit: Lilian Soon.

Volume 30 Issue 7

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Editorial

  • Wanted: faster, more effective ways of testing experimental cancer drugs for both single-agent and combination treatments.

    Editorial

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News

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News Feature

  • Since the discovery of circulating tumor cells in 1869, researchers have been able to do little else beyond count them. This is about to change, as advanced technologies for harvesting and analyzing rare cells from blood are opening the window for characterization. Jim Kling reports.

    • Jim Kling
    News Feature

  • Coinciding with last month's annual meeting of the American Society of Clinical Oncology, at least one business launched with a plan to use genetic information from patient tumors to help guide treatment. Michael Eisenstein investigates.

    • Michael Eisenstein
    News Feature
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Bioentrepreneur

  • Academic researchers often need to stand out to advance, but the corporate world calls for team players. Moving from one world to the other can be a culture shock.

    • Gwen Acton
    • Alicia Gómez-Yafal
    • Emily Walsh
    Bioentrepreneur
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Correspondence

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Commentary

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Feature

  • Despite impressive clinical activity in B-cell lymphoma and melanoma, questions remain about the immunobiology of adoptive T-cell therapies.

    • Carl June
    • Steven A Rosenberg
    • Jeffrey S Weber
    Feature
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Patents

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News & Views

  • Calculating absolute copy numbers in cancer genome sequences identifies disease-associated genes and provides insights into tumor evolution and heterogeneity.

    • Peter Van Loo
    • Peter J Campbell
    News & Views

  • Oligonucleotides with unnatural sugar backbones that can be replicated in vitro may open up new avenues for synthetic biology and beyond.

    • Fintan R Steele
    • Larry Gold
    News & Views
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Research Highlights

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Commentary

  • Algorithms that compute directly on compressed genomic data allow analyses to keep pace with data generation.

    • Po-Ru Loh
    • Michael Baym
    • Bonnie Berger
    Commentary
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Perspective

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Review Article

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Article

  • Single-molecule sequencing technologies can produce multikilobase-long reads, which are more useful than short reads for assembling genomes and transcriptomes, but their error rates are too high. Koren et al. correct long reads from a PacBio instrument using high-fidelity, short reads from complementary technologies, facilitating assembly of previously intractable sequences.

    • Sergey Koren
    • Michael C Schatz
    • Adam M Phillippy

    Collection:

    Article

  • The multikilobase reads that can be produced by single-molecule sequencing technologies may span complex, repetitive genomic regions but have high error rates. Bashir et al. use these reads to organize contigs assembled from accurate, short-read data, facilitating the analysis of clinically important regions of an outbreak strain of cholera.

    • Ali Bashir
    • Aaron A Klammer
    • Eric E Schadt
    Article

  • Khmelinskii et al. describe tandem fluorescent protein timers for measuring protein turnover and trafficking in living cells. Data from a single time point are used to determine protein stability, allowing the authors to screen for components of protein degradation pathways.

    • Anton Khmelinskii
    • Philipp J Keller
    • Michael Knop
    Article
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Letter

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Careers and Recruitment

  • A manager's ability to provide knowledge workers with the personalized goals, motivation and tools they need to perform at their best will bring outstanding results.

    • Sebastiano Massaro
    Careers and Recruitment

  • Careers and Recruitment
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In This Issue

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Focus

  • Increased understanding of the molecular defects associated with malignancies is opening up new opportunities in diagnosis and therapy. This focus issue of Nature Biotechnology highlights a selection of new technologies that promise to facilitate the development of more effective cancer treatments.

    Focus
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