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Volume 29 Issue 9, September 2011

Staining of a novel glycan antigen, SSEA-5, expressed on human pluripotent stem cells reveals two inner cell masses in a human monozygotictwin blastocyst. Drukker and colleagues use SSEA-5 to remove rare tumor-forming cells from cultures of differentiated human embryonic stem cells (p 829). Credit: Chad Tang

Volume 29 Issue 9

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Editorial

  • Whole-genome sequencing and crowdsourced analyses proved a powerful adjunct to traditional typing in the recent Escherichia coli outbreak.

    Editorial

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News

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Data Page

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News Feature

  • For a century, insulin has been the only drug available to type 1 diabetics. Now a raft of novel drugs are coming through the pipeline. Michael Eisenstein reports.

    • Michael Eisenstein
    News Feature
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Correspondence

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Patents

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News & Views

  • A newly identified surface marker on human embryonic stem cells allows rare tumor-forming cells to be removed from preparations of differentiated cells.

    • Peter W Andrews
    News & Views

  • The convergence of semiconductor chips and DNA sequencing begets a strong contender in the race to build the best sequencers.

    • Keith Robison
    News & Views

  • Alteration of a stop codon across an entire bacterial genome opens the way to exploring the biotech potential of synthetic genetic codes.

    • Yizhi Cai
    • Jef D Boeke
    News & Views
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Research Highlights

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Commentary

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Article

  • Zinc-finger nucleases allow targeted genetic modification at loci chosen by the investigator, but the extent of their off-target activity—which could be toxic to cells—has not been evaluated experimentally on a genome-wide scale. Gabriel et al. document the off- and on-target activity of zinc-finger nucleases using lentiviral vectors to tag integration sites.

    • Richard Gabriel
    • Angelo Lombardo
    • Christof von Kalle
    Article
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Letter

  • The similarities and differences between the disease mechanisms underlying the sporadic and familial forms of amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) are poorly characterized. Using human astrocytes derived from neural progenitor cells obtained from cadaveric spinal cords, Haidet-Phillips et al. propose that sporadic and familial ALS share common pathogenic pathways involving astrocyte-mediated damage.

    • Amanda M Haidet-Phillips
    • Mark E Hester
    • Brian K Kaspar
    Letter

  • Using cells derived from human pluripotent stem cells for therapeutic applications carries a risk that rare undifferentiated cells in the transplant will give rise to teratomas. Tang et al. identify a new antigen on the surface of human pluripotent cells that, combined with other antigens, enables complete depletion of teratoma-initiating cells.

    • Chad Tang
    • Andrew S Lee
    • Micha Drukker
    Letter

  • Imaging the spatial and temporal complexity of molecules in living cells and tissues could provide important data for a quantitative understanding of biology. Capoulade et al. introduce a light sheet–based microscope that performs fluorescence correlation spectroscopy at each pixel of an image to provide spatially resolved maps of protein dynamics.

    • Jérémie Capoulade
    • Malte Wachsmuth
    • Michael Knop
    Letter
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Resource

  • Prosser et al. describe a resource of mouse embryonic stem cell clones harboring deletions that target 392 microRNA loci.. Because the targeting cassettes can be readily replaced by reporter genes, conditional alleles and other variants, the lines should facilitate a broad range of studies into microRNA function.

    • Haydn M Prosser
    • Hiroko Koike-Yusa
    • Allan Bradley
    Resource
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Careers and Recruitment

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