Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 29 Issue 2, February 2011

How transcription activator–like effectors (TALEs) bind DNA is unknown. A nuclear magnetic resonance structure of a single TALE repeat was used to model two DNA-bound TALEs, each comprising 13 repeats. Also shown are two FokI nuclease domains based on a crystal structure. Miller et al. use TALE – nuclease fusions for genome targeting in human cells (p 143). Image credit: Jeffrey C. Miller, Sangamo Biosciences.

Volume 29 Issue 2

Subscribe

Editorial

  • The Chinese market is a big draw for biotech investors, but overreliance on central control and insular vision could derail the sector.

    Editorial

    Advertisement

  • The Obama administration's hint at regulatory rollback may make stricter oversight of direct-to-consumer (DTC) genetic testing less inevitable, particularly as fresh evidence on consumer attitudes suggests buyers can handle the information.

    Editorial
Top of page ⤴

News

Top of page ⤴

Data Page

Top of page ⤴

News Feature

  • With information on the Deepwater Horizon oil spill in the Gulf of Mexico still coming in, more is being learned about the role of indigenous bacteria in cleaning the spill. Meanwhile, efforts are under way to enlist new genomic technologies to improve outcomes. Jeffrey L. Fox reports.

    • Jeffrey L. Fox
    News Feature

  • One-size-fits-all intravenous delivery of biologics may be giving way to alternate delivery routes that enable safer and more efficient drug administration. Michael Eisenstein reports.

    • Michael Eisenstein
    News Feature
Top of page ⤴

Correspondence

Top of page ⤴

Book Review

Top of page ⤴

Feature

  • Gene therapy is finally poised to make a contribution to the treatment of debilitating, highly penetrant genetic diseases that have proved intractable to other regimens.

    • Cormac Sheridan
    Feature
Top of page ⤴

Patents

Top of page ⤴

News & Views

  • New tools for site-specific genome targeting in human cells are generated from TALE proteins.

    • Jens Boch
    News & Views

  • The use of a natural IgG transport system to deliver a mucosal vaccine is a step toward needle-free immunization.

    • Jerry R McGhee
    News & Views

  • Sequencing technologies are poised to transform conventional strategies for crop improvement.

    • Jer-Ming Chia
    • Doreen Ware
    News & Views
Top of page ⤴

Research Highlights

Top of page ⤴

Profile

  • Reflecting on the growth of bioinformatics over the past decade, the University of Pennsylvania's David Roos highlights the increasing diversity of large-scale data sets, changing paradigms for data release and the emergence of new career opportunities.

    • H. Craig Mak
    Profile
Top of page ⤴

Article

  • TALEs (transcription activator-like effectors) are transcription factors from the plant pathogen Xanthomonas that can be readily engineered to bind new DNA sequences of interest. Miller et al. use a truncated TALE linked to a nuclease domain to edit and regulate endogenous genes in human cells.

    • Jeffrey C Miller
    • Siyuan Tan
    • Edward J Rebar
    Article
Top of page ⤴

Letter

  • Messenger RNA has received little attention as a potential therapeutic agent. Kormann et al. show that intramuscular injection of chemically modified erythropoietin mRNA substantially increases the hematocrit in mice and demonstrate the curative potential of pulmonary mRNA delivery in a mouse model of congenital surfactant protein B deficiency.

    • Michael S D Kormann
    • Günther Hasenpusch
    • Carsten Rudolph
    Letter

  • Ye et al. mimic a natural pathway for IgG transfer to deliver a vaccine across mucosal barriers. Intranasal immunization of mice with a fusion of a herpes simplex virus type-2 (HSV-2) antigen to an Fc fragment induces long-lasting protection after intravaginal challenge with HSV-2.

    • Lilin Ye
    • Rongyu Zeng
    • Xiaoping Zhu
    Letter

  • Synthetic biology requires methods for modular, scalable control of gene expression. Liu et al. show that unnatural amino acids can be used to regulate transcription and use the approach to create NOR and OR gates.

    • Chang C Liu
    • Lei Qi
    • Adam P Arkin
    Letter
Top of page ⤴

Careers and Recruitment

Top of page ⤴

Search

Advanced search

Quick links