To the Editor:
Compositional equivalence of crops improved through biotech-derived transgenic, or genetically modified (GM), traits and their conventional (non-GM) comparators is an important criterion in breeding as well as a key aspect of risk assessments of commercial candidates. We present here an analysis evaluated from compositional data on GM corn and GM soybean varieties grown across a range of geographies and growing seasons with the aim of not only assessing the relative impact of transgene insertion on compositional variation in comparison with the effect of environmental factors but also reviewing the implications of these results on the safety assessment process. Specifically, our analysis includes evaluation of seven GM crop varieties from a total of nine countries and eleven growing seasons. On the basis of our data, we conclude that compositional differences between GM varieties and their conventional comparators were encompassed within the natural variability of the conventional crop and that the composition of GM and conventional crops cannot be disaggregated.
At a glance
- OECD. Report of the OECD Workshop on the Toxicological and Nutritional Testing of Novel Foods (Organisation for Economic Co-operation and Development, Paris, 1998).
- OECD. An Introduction to the Food/Feed Safety Consensus Documents of the Task Force (Organization for Economic Cooperation and Development, Paris, 2006).
- Proteomics 7, 597–604 (2007). et al.
- J. Agric. Food Chem. 53, 10061–10067 (2005). , , , &
- J. Agric. Food Chem. 55, 6177–6185 (2007). et al.
- 2008). Executive Summary of Global Status of Commercialized Biotech/GM Crops: 2008. ISAAA Briefs No. 39 (International Service for the Acquisition of Agri-Biotech Applications, Ithaca, New York,
- Regul. Toxicol. Pharmacol. 44, 125–135 (2006). &
- National Research Council and Insitute of Medicine of the National Academies. Safety of Genetically Engineered Foods. Approaches to Assessing Unintended Health Effects (The National Academies Press, Washington, DC, 2004).
- Nat. Biotechnol. 25, 725–727 (2007).
- Nat. Biotechnol. 23, 439–444 (2005). , , , &
- Nat. Biotechnol. 27, 702–704 (2009). , &
- Nat. Biotechnol. 27, 519–527 (2009). , , &
- Nat. Biotechnol. 25, 981–987 (2007).
- AgBioForum 11, 21–38 (2008). &
- Pest Manag. Sci. 63, 1107–1115 (2007). et al.
- Supplementary Text and Figures (716K)
Supplementary Tables 1–21, Supplementary Figs. 1–24, Supplementary Methods, Supplementary Notes and Supplementary References