Problems in interpreting diagnostic tests for HER2 may be compromising patient access to effective treatments. As new versions of therapies targeting HER2 work their way through clinical trials, will the situation get even murkier? Malorye Allison investigates.
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References
Phillips, K.A. et al. Cancer 115, 5166–5174 (2009).
McArthur, H.L. & Hudis, C. Clin. Cancer Res. 15, 6311–6313 (2009).
Perez, E.A. et al. J. Clin. Oncol. 25, 512, Suppl. 18S (2007).
McArthur, H.L. et al., abstract 1005, presented at European CanCer Organization 15 and 34th European Society for Medical Oncology Multidisciplinary Congress, Berlin, Sept. 20–24, 2009.
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Allison, M. The HER2 testing conundrum. Nat Biotechnol 28, 117–119 (2010). https://doi.org/10.1038/nbt0210-117
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DOI: https://doi.org/10.1038/nbt0210-117
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