Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Patents
  • Published:

The intellectual property landscape for gene suppression technologies in plants

Nature Biotechnology volume 28, pages 32–36 (2010)Cite this article

Subjects

Reviewing the major features in the patent landscape of RNA-mediated gene suppression may aid the development of patent strategies that will support the next generation of genetically modified crops.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Scientific and US intellectual property milestones in RNA-mediated gene suppression in plant biotech.
Figure 2: RNA Gene-silencing constructs commonly used in plant genetic modification.

References

  1. Schmidt, C. Nat. Biotechnol. 25, 273–275 (2007).

    Article  CAS  Google Scholar 

  2. Howard, K. Nat. Biotechnol. 21, 1441–1446 (2003).

    Article  CAS  Google Scholar 

  3. Simons, R.W. Gene 72, 35–44 (1988).

    Article  CAS  Google Scholar 

  4. Ecker, J.R. & Davis, R.W. Proc. Natl. Acad. Sci. USA 83, 5372–5376 (1986).

    Article  CAS  Google Scholar 

  5. Rothstein, S.J., Dimaio, J., Strand, M. & Rice, D. Proc. Natl. Acad. Sci. USA 84, 8439–8443 (1987).

    Article  CAS  Google Scholar 

  6. Delauney, A.J., Tabaeizadeh, Z. & Verma, D.P. Proc. Natl. Acad. Sci. USA 85, 4300–4304 (1988).

    Article  CAS  Google Scholar 

  7. van der Krol, A.R. et al. Nature 333, 866–869 (1988).

    Article  CAS  Google Scholar 

  8. Sheehy, R.E., Kramer, M. & Hiatt, W.R. Proc. Natl. Acad. Sci. USA 85, 8805–8809 (1988).

    Article  CAS  Google Scholar 

  9. Smith, C.J.S. et al. Nature 334, 724–726 (1988).

    Article  CAS  Google Scholar 

  10. Rodermel, S.R., Abbott, M.S. & Bogorad, L. Cell 55, 673–681 (1988).

    Article  CAS  Google Scholar 

  11. van der Krol, A.R., Mur, L.A., Beld, M., Mol, J.N. & Stuitje, A.R. Plant Cell 2, 291–299 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. van der Krol, A.R., Mur, L.A., de Lange, P., Mol, J.N. & Stuitje, A.R. Plant Mol. Biol. 14, 457–466 (1990).

    Article  CAS  Google Scholar 

  13. Napoli, C., Lemieux, C. & Jorgensen, R. Plant Cell 2, 279–289 (1990).

    Article  CAS  Google Scholar 

  14. Fire, A. et al. Nature 391, 806–811 (1998).

    Article  CAS  Google Scholar 

  15. Pang, S.Z., Slightom, J.L. & Gonsalves, D. Bio-Technology (NY) 11, 819–824 (1993).

    CAS  Google Scholar 

  16. Lindbo, J.A. & Dougherty, W.G. Virology 189, 725–733 (1992).

    Article  CAS  Google Scholar 

  17. Metzlaff, M., O'Dell, M., Cluster, P.D. & Flavell, R.B. Cell 88, 845–854 (1997).

    Article  CAS  Google Scholar 

  18. Stam, M., Viterbo, A., Mol, J.N. & Kooter, J.M. Mol. Cell. Biol. 18, 6165–6177 (1998).

    Article  CAS  Google Scholar 

  19. Montgomery, M.K., Xu, S. & Fire, A. Proc. Natl. Acad. Sci. USA 95, 15502–15507 (1998).

    Article  CAS  Google Scholar 

  20. Waterhouse, P.M., Graham, M.W. & Wang, M.B. Proc. Natl. Acad. Sci. USA 95, 13959–13964 (1998).

    Article  CAS  Google Scholar 

  21. Hamilton, A.J. & Baulcombe, D.C. Science 286, 950–952 (1999).

    Article  CAS  Google Scholar 

  22. Smith, N.A. et al. Nature 407, 319–320 (2000).

    Article  CAS  Google Scholar 

  23. Brummell, D.A. et al. Plant J. 33, 793–800 (2003).

    Article  CAS  Google Scholar 

  24. Shewmaker, C.K., Kridl, J.C., Hiatt, W.R., Knauf, V. US Patent no. 5,107,065 (1992).

  25. Shewmaker, C.K., Kridl, J.C. ; Hiatt, W.R., Knauf V. US Patent no. 5,759,829 (1998).

  26. Sanders, R.A. & Hiatt, W. Nat. Biotechnol. 23, 287–289 (2005).

    Article  CAS  Google Scholar 

  27. Jorgensen, R.A. & Napoli, C.A. US Patent no. 5,231,020 (1993).

  28. Jorgensen, R.A. & Napoli, C.A. US Patent no. 5,283,184 (1994).

  29. Fire, A., et al. US Patent no. 6,506,559 (2003).

  30. Graham, M.W. US Patent no. 6,573,099 (2003).

  31. Fenton GM, C Chi-Ham and S Boettiger . Freedom to operate: The law firms approach and role. in Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices (eds. A Krattiger, RT Mahoney, L Nelsen, et al. MIHR, Oxford, UK & PIPRA, Davis, US) (2007).

  32. Kramer, M. & Redenbaugh, K. Euphytica 79, 293–297 (1994).

    Article  Google Scholar 

Download references

Acknowledgements

We thank J. Harvey and R. Riley-Vargas for critical discussion and contributions to this paper. We are grateful to N. Fong for graphic assistance.

Author information

Authors and Affiliations

  1. Cecilia L. Chi-Ham, Kerri L. Clark and Alan B. Bennett are at the Public Intellectual Property Resource for Agriculture, University of California Davis, Davis, California, USA.,

    Cecilia L Chi-Ham, Kerri L Clark & Alan B Bennett

Authors
  1. Cecilia L Chi-Ham
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kerri L Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alan B Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alan B Bennett.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chi-Ham, C., Clark, K. & Bennett, A. The intellectual property landscape for gene suppression technologies in plants. Nat Biotechnol 28, 32–36 (2010). https://doi.org/10.1038/nbt0110-32

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0110-32

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing