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Synthetic metabolic pipelines

Nature Biotechnology volume 27, pages 728–729 (2009)Cite this article

Controlling the spatial organization of sequential metabolic enzymes may provide a general strategy for increasing the production of valuable compounds.

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Figure 1: An engineered pipeline for mevalonate production in E. coli comprising an optimized ratio of three metabolic enzymes assembled on a modular protein scaffold.

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Authors and Affiliations

  1. Matthew P. DeLisa and Robert J. Conrado are at the School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.,

    Matthew P DeLisa & Robert J Conrado

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  1. Matthew P DeLisa
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  2. Robert J Conrado
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Correspondence to Matthew P DeLisa.

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DeLisa, M., Conrado, R. Synthetic metabolic pipelines. Nat Biotechnol 27, 728–729 (2009). https://doi.org/10.1038/nbt0809-728

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