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Computational Biology

Nature Biotechnology 27, 627–632 (1 July 2009) | doi:10.1038/nbt.1552

Fifteen years of microbial genomics: meeting the challenges and fulfilling the dream

Nikos C Kyrpides

The dramatic advancements in sequencing technology achieved during the past decade have mediated a rapid transition from single-gene to whole-genome studies. In so doing, they also transformed what had been an almost purely experimental discipline into a predominantly theoretical and predictive one.