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Nature Biotechnology 27, 349 - 351 (2009)
doi:10.1038/nbt0409-349
SNP imputation in association studies
Eran Halperin1 & Dietrich A Stephan2
Abstract
Only a subset of single-nucleotide polymorphisms (SNPs) can be genotyped in genome-wide association studies. Imputation methods can infer the alleles of 'hidden' variants and use those inferences to test the hidden variants for association.
- Eran Halperin is at the International Computer Science Institute, Berkeley, California, USA, and the Blavatnik School of Computer Science and the Department of Biotechnology, Tel Aviv University, Tel Aviv, Israel.
- Dietrich A. Stephan is in the Division of Genomics Research, Navigenics, Foster City, California, USA.
Correspondence to: Dietrich A Stephan2 e-mail: dietrich@navigenics.com
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