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Research
Nature Biotechnology 27, 199–204 (1 February 2009) | doi:10.1038/nbt.1522
Dynamic modularity in protein interaction networks predicts breast cancer outcome
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Abstract
Changes in the biochemical wiring of oncogenic cells drives phenotypic transformations that directly affect disease outcome. Here we examine the dynamic structure of the human protein interaction network (interactome) to determine whether changes in the organization of the interactome can be used to predict patient outcome.
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