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Research
Nature Biotechnology 27, 169–171 (1 February 2009) | doi:10.1038/nbt.1520
Transgenic mice with defined combinations of drug-inducible reprogramming factors
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Abstract
Proviruses carrying drug-inducible Oct4, Sox2, Klf4 and c-Myc used to derive 'primary' induced pluripotent stem (iPS) cells were segregated through germline transmission, generating mice and cells carrying subsets of the reprogramming factors. Drug treatment produced 'secondary' iPS cells only when the missing factor was introduced.
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