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GPS navigation of the protein-stability landscape

Nature Biotechnology volume 27, pages 46–48 (2009)Cite this article

Protein stability can now be studied in a high-throughput fashion at single-cell resolution.

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Figure 1: Global protein stability (GPS) profiling.

References

  1. Yen, H.C. et al. Science 322, 918–923 (2008).

    Article  CAS  Google Scholar 

  2. Yen, H.C. & Elledge, S.J. Science 322, 923–929 (2008).

    Article  CAS  Google Scholar 

  3. Evans, T. et al. Cell 33, 389–396 (1983).

    Article  CAS  Google Scholar 

  4. Beynon, R.J. & Pratt, J.M. Mol. Cell. Proteomics 4, 857–872 (2005).

    Article  CAS  Google Scholar 

  5. Belle, A. et al. Proc. Natl. Acad. Sci. USA 103, 13004–13009 (2006).

    Article  CAS  Google Scholar 

  6. Petroski, M.D. BMC Biochem. 9 (Suppl 1):S7 (2008).

    Article  Google Scholar 

  7. Krutzik, P.O. & Nolan, G.P. Nat. Methods 3, 361–368 (2006).

    Article  CAS  Google Scholar 

  8. Krutzik, P.O., Crane, J.M., Clutter, M.R. & Nolan, G.P. Nat. Chem. Biol. 4, 132–142 (2008).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Donald S. Kirkpatrick is in the Department of Protein Chemistry, Genentech, Inc., 1 DNA Way, S. San Francisco, California 94080, USA. donaldk@gene.com,

    Donald S Kirkpatrick

  2. Vishva M. Dixit is in the Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, S. San Francisco, California 94080, USA. dixit@gene.com,

    Vishva M Dixit

Authors
  1. Donald S Kirkpatrick
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  2. Vishva M Dixit
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Kirkpatrick, D., Dixit, V. GPS navigation of the protein-stability landscape. Nat Biotechnol 27, 46–48 (2009). https://doi.org/10.1038/nbt0109-46

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