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Volume 26 Issue 9, September 2008

A microfluidic affinity analysis device with > 7,000 valves is capable of performing thousands of parallel experiments. Einav et al. use this device to isolate a small molecule against the HCV target NS4B (p 1019). Credit: Doron Gerber.

Volume 26 Issue 9

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Editorial

  • Disease-orientated consumer online communities radically change the way in which individuals monitor their health, but they could also create new ways of testing treatments and speed patient recruitment into clinical trials.

    Editorial

    Advertisement

  • Does a role-playing game reveal any new insights into the factors holding back the UK biotech sector?

    Editorial
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News

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News Feature

  • The FDA's Office of Oncology Products has come in for stinging criticism from drug developers, advocates and even a US legislator over the use of surrogate endpoints. Has the agency struck the right balance between speed and caution? Malorye Allison investigates.

    • Malorye Allison
    News Feature
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Correspondence

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Commentary

  • To what extent is the existing framework for biosimilars in Europe likely to be applicable to monoclonal antibodies?

    • Christian K Schneider
    • Ulrich Kalinke
    Commentary
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Book Review

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Patents

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News & Views

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Analysis

  • Metabolic network modeling in multicellular organisms is confounded by the existence of multiple tissues with distinct metabolic functions. By integrating a genome-scale metabolic network with tissue-specific gene- and protein-expression data, Shlomi et al. adapt constraint-based approaches used for microorganisms to predicting metabolism in ten human tissues. Their computational approach should facilitate interpretation of expression data in the context of metabolic disorders.

    • Tomer Shlomi
    • Moran N Cabili
    • Eytan Ruppin

    Collection:

    Analysis
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Primer

  • Decision trees have been applied to problems such as assigning protein function and predicting splice sites. How do these classifiers work, what types of problems can they solve and what are their advantages over alternatives?

    • Carl Kingsford
    • Steven L Salzberg

    Collection:

    Primer
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Brief Communication

  • Backbone fragments of the Agrobacterium tumor-inducing (Ti) plasmid that bears transgenes of interest have occasionally been reported to be transferred to plant genomes. Now, Ülker et al. show that Agrobacterium chromosomal DNA can also be integrated into transgenic plants at a low frequency. Gene-bearing chromosomal fragments as large as 18 kb are found in T-DNA–tagged populations of Arabidopsis thaliana.

    • Bekir Ülker
    • Yong Li
    • Bernd Weisshaar
    Brief Communication
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Article

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Letter

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Careers and Recruitment

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People

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