Table of contents
June 2008, Volume 26 No 6 pp607-714
- In This Issue
- Bioentrepreneur
- Editorial
- News
- Opinion and Comment
- Features
- News and Views
- Computational Biology
- Research
- Naturejobs
Editorial
What you don't know will hurt you - p589
doi:10.1038/nbt0608-589
The heparin scare highlights the need not only for more effective systems of adverse event reporting and product tracking, but also for drug makers to tighten scrutiny of their suppliers.
Abstract - | Full Text - What you don't know will hurt you | PDF (112 KB) - What you don't know will hurt you
News
HIV vaccine developers battle on, despite high-profile failures - pp591 - 592
Heidi Ledford
doi:10.1038/nbt0608-591
Full Text - HIV vaccine developers battle on, despite high-profile failures | PDF (721 KB) - HIV vaccine developers battle on, despite high-profile failures
FDA balks at Myozyme scale-up - p592
George Mack
doi:10.1038/nbt0608-592
Full Text - FDA balks at Myozyme scale-up | PDF (89 KB) - FDA balks at Myozyme scale-up
Millennium ends Takeda's US shopping spree - pp593 - 595
Douglas Sipp
doi:10.1038/nbt0608-593
Full Text - Millennium ends Takeda's US shopping spree | PDF (412 KB) - Millennium ends Takeda's US shopping spree
GSK moves on Sirtris - p595
Douglas Sipp
doi:10.1038/nbt0608-595
Full Text - GSK moves on Sirtris | PDF (113 KB) - GSK moves on Sirtris
Agency on hiring spree - p596
Emily Waltz
doi:10.1038/nbt0608-596a
Full Text - Agency on hiring spree | PDF (156 KB) - Agency on hiring spree
University patents probed - p596
Emily Waltz
doi:10.1038/nbt0608-596b
Full Text - University patents probed | PDF (156 KB) - University patents probed
Industry welcomes Genetic Information Nondiscrimination Act - pp596 - 597
Malorye Allison
doi:10.1038/nbt0608-596c
Full Text - Industry welcomes Genetic Information Nondiscrimination Act | PDF (175 KB) - Industry welcomes Genetic Information Nondiscrimination Act
Patent reform stalls - p597
Amy Coombs
doi:10.1038/nbt0608-597a
Full Text - Patent reform stalls | PDF (72 KB) - Patent reform stalls
In silico vaccine - p597
Henry Nicholls
doi:10.1038/nbt0608-597b
Full Text - In silico vaccine | PDF (72 KB) - In silico vaccine
FDA scrutinizes human stem cell therapies - pp598 - 599
Jeffrey L Fox
doi:10.1038/nbt0608-598
Full Text - FDA scrutinizes human stem cell therapies | PDF (556 KB) - FDA scrutinizes human stem cell therapies
Canada charts biologics path - p599
Hannah Hoag
doi:10.1038/nbt0608-599a
Full Text - Canada charts biologics path | PDF (71 KB) - Canada charts biologics path
FDA gets personal - p599
Henry Nicholls
doi:10.1038/nbt0608-599b
Full Text - FDA gets personal | PDF (71 KB) - FDA gets personal
Profile: Fred Kavli - p600
Joe Alper
doi:10.1038/nbt0608-600
Fred Kavli is a visionary philanthropist who began selling wood briquettes in wartime Norway and is now investing his fortune in keeping blue-sky research alive.
Abstract - | Full Text - Profile: Fred Kavli | PDF (131 KB) - Profile: Fred Kavli
Data Page
Partnerships remain buoyant - p602
Stacy Lawrence
doi:10.1038/nbt0608-602
Full Text - Partnerships remain buoyant | PDF (170 KB) - Partnerships remain buoyant
News Feature
When animal rights turns ugly - pp603 - 605
doi:10.1038/nbt0608-603
Despite tightened legislation against animal rights extremism, activists are increasing attacks on academics and researchers in big pharma. How much of a threat do they pose to researchers working in biotech? Brady Huggett investigates.
Abstract - | Full Text - When animal rights turns ugly | PDF (248 KB) - When animal rights turns ugly
Bioentrepreneur
Building a business
Leveraging your biotech intellectual property - pp607 - 609
Michael B Harlin & Kevin A O'Connor
doi:10.1038/bioe.2008.5
Opinion and Comment
Correspondence
Predicting disease outcomes in the clinic - pp611 - 612
Mark A Jensen
doi:10.1038/nbt0608-611
Full Text - Predicting disease outcomes in the clinic | PDF (175 KB) - Predicting disease outcomes in the clinic
Response to Predicting disease outcomes in the clinic - pp612 - 613
doi:10.1038/nbt0608-612
Full Text - Response to Predicting disease outcomes in the clinic | PDF (135 KB) - Response to Predicting disease outcomes in the clinic
Caring about microenvironments - pp613 - 614
Cameron Lutton & Ben Goss
doi:10.1038/nbt0608-613
Full Text - Caring about microenvironments | PDF (143 KB) - Caring about microenvironments
Fallout from flip-flops - pp614 - 615
Paul Froese
doi:10.1038/nbt0608-614
Full Text - Fallout from flip-flops | PDF (98 KB) - Fallout from flip-flops
Forest biotech and climate change - pp615 - 617
Trevor M Fenning, Christian Walter & Kevan M A Gartland
doi:10.1038/nbt0608-615
Full Text - Forest biotech and climate change | PDF (109 KB) - Forest biotech and climate change
A cautionary note on pathogen-derived sequences - pp617 - 619
Alessandra Lucioli, David E Sallustio, Daniele Barboni, Alessandra Berardi, Velia Papacchioli, Raffaela Tavazza & Mario Tavazza
doi:10.1038/nbt0608-617
Full Text - A cautionary note on pathogen-derived sequences | PDF (253 KB) - A cautionary note on pathogen-derived sequences | Supplementary information
Commentary
The FDA and safety—beyond the heparin crisis - pp621 - 623
Cato T Laurencin & Lakshmi Nair
doi:10.1038/nbt0608-621
The discovery of a contaminant in batches of heparin throws into stark relief the difficulties, not only for the US Food and Drug Administration, but also for international regulatory agencies, to ensure the safety and quality of active pharmaceutical ingredients.
Abstract - | Full Text - The FDA and safety—beyond the heparin crisis | PDF (272 KB) - The FDA and safety—beyond the heparin crisis
Canaries, coal mines and the drug supply - pp624 - 626
Jeffrey M Leiden
doi:10.1038/nbt0608-624
The heparin safety crisis sends a strong signal that urgent changes in regulatory and manufacturing oversight are needed to ensure the safety of the global drug supply.
Abstract - | Full Text - Canaries, coal mines and the drug supply | PDF (124 KB) - Canaries, coal mines and the drug supply
Features
Brazilian health biotech—fostering crosstalk between public and private sectors - pp627 - 644 FREE
Rahim Rezaie, Sarah E Frew, Stephen M Sammut, Maya R Maliakkal, Abdallah S Daar & Peter A Singer
doi:10.1038/nbt0608-627
Brazil boasts world-class biomedical science, but tension between the public and private sectors hinders progress in health biotech innovation.
Abstract - | Full Text - Brazilian health biotech—fostering crosstalk between public and private sectors | PDF (1,212 KB) - Brazilian health biotech—fostering crosstalk between public and private sectors | Supplementary information
Patents
Patent protection and access to genetic resources - pp645 - 647
Itsuki Shimbo, Yoko Ito & Koichi Sumikura
doi:10.1038/nbt0608-645
Developing countries and patent offices have shown differing approaches to patent specification disclosure requirements and benefit sharing.
Abstract - | Full Text - Patent protection and access to genetic resources | PDF (108 KB) - Patent protection and access to genetic resources
Recent patent applications in biological imaging - p648
doi:10.1038/nbt0608-648
Full Text - Recent patent applications in biological imaging | PDF (41 KB) - Recent patent applications in biological imaging
News and Views
Next-generation sequencing-by-hybridization - pp649 - 650
Paul M Lizardi
doi:10.1038/nbt0608-649
A new hybridization-based technology offers advantages in sequencing genomes for which a reference genome exists.
Abstract - | Full Text - Next-generation sequencing-by-hybridization | PDF (125 KB) - Next-generation sequencing-by-hybridization
See also: Research by Pihlak et al.
Targeted mutagenesis in zebrafish - pp650 - 651
Ian G Woods & Alexander F Schier
doi:10.1038/nbt0608-650
Directed gene knockout in a vertebrate has been achieved using zinc-finger nucleases.
Abstract - | Full Text - Targeted mutagenesis in zebrafish | PDF (276 KB) - Targeted mutagenesis in zebrafish
See also: Research by Meng et al. | Research by Doyon et al.
Proteases' prime targets revealed - pp652 - 653
Scott L Diamond & Doron Greenbaum
doi:10.1038/nbt0608-652
Mass spectrometry analysis of proteome-derived peptide libraries enables high-throughput determination of protease substrate specificity.
Abstract - | Full Text - Proteases' prime targets revealed | PDF (170 KB) - Proteases' prime targets revealed
See also: Research by Schilling & Overall
Stable transgenes bear fruit - pp653 - 654
Ajay Kohli & Paul Christou
doi:10.1038/nbt0608-653
Analysis of the transgenic papaya genome sequence suggests that transgenes generally stay put following integration and can achieve stable expression level from generation to generation.
Abstract - | Full Text - Stable transgenes bear fruit | PDF (169 KB) - Stable transgenes bear fruit
A new path to the cancer epigenome - pp655 - 656
Victoria M Richon
doi:10.1038/nbt0608-655
A regulator of the spatial organization of chromatin may be a promising target to curb the invasiveness of breast cancer.
Abstract - | Full Text - A new path to the cancer epigenome | PDF (264 KB) - A new path to the cancer epigenome
Research Highlights - p657
doi:10.1038/nbt0608-657
Full Text - Research Highlights | PDF (125 KB) - Research Highlights
Computational Biology
Review
The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli - pp659 - 667
Adam M Feist & Bernhard Ø Palsson
doi:10.1038/nbt1401
Abstract - | Full Text - The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli | PDF (736 KB) - The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli | Supplementary information
Research
Articles
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events - pp669 - 675
Marco Guerrini, Daniela Beccati, Zachary Shriver, Annamaria Naggi, Karthik Viswanathan, Antonella Bisio, Ishan Capila, Jonathan C Lansing, Sara Guglieri, Blair Fraser, Ali Al-Hakim, Nur Sibel Gunay, Zhenqing Zhang, Luke Robinson, Lucinda Buhse, Moheb Nasr, Janet Woodcock, Robert Langer, Ganesh Venkataraman, Robert J Linhardt, Benito Casu, Giangiacomo Torri & Ram Sasisekharan
doi:10.1038/nbt1407
Abstract - | Full Text - Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events | PDF (2,996 KB) - Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events | Supplementary information
Rapid genome sequencing with short universal tiling probes - pp676 - 684
Arno Pihlak, Göran Baurén, Ellef Hersoug, Peter Lönnerberg, Ats Metsis & Sten Linnarsson
doi:10.1038/nbt1405
Abstract - | Full Text - Rapid genome sequencing with short universal tiling probes | PDF (930 KB) - Rapid genome sequencing with short universal tiling probes | Supplementary information
See also: News and Views by Lizardi
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites - pp685 - 694
Oliver Schilling & Christopher M Overall
doi:10.1038/nbt1408
Abstract - | Full Text - Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites | PDF (678 KB) - Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites | Supplementary information
See also: News and Views by Diamond & Greenbaum
Letters
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases - pp695 - 701
Xiangdong Meng, Marcus B Noyes, Lihua J Zhu, Nathan D Lawson & Scot A Wolfe
doi:10.1038/nbt1398
First Paragraph - | Full Text - Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases | PDF (489 KB) - Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases | Supplementary information
See also: News and Views by Woods & Schier
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases - pp702 - 708
Yannick Doyon, Jasmine M McCammon, Jeffrey C Miller, Farhoud Faraji, Catherine Ngo, George E Katibah, Rainier Amora, Toby D Hocking, Lei Zhang, Edward J Rebar, Philip D Gregory, Fyodor D Urnov & Sharon L Amacher
doi:10.1038/nbt1409
First Paragraph - | Full Text - Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases | PDF (331 KB) - Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases | Supplementary information
See also: News and Views by Woods & Schier
Errata
Erratum: Tony Conner - p709
Jim Kling
doi:10.1038/nbt0608-709a
Full Text - Erratum: Tony Conner | PDF (53 KB) - Erratum: Tony Conner
Erratum: Antivirals become a broader enterprise - p709
Jeffrey L Fox
doi:10.1038/nbt0608-709b
Full Text - Erratum: Antivirals become a broader enterprise | PDF (53 KB) - Erratum: Antivirals become a broader enterprise
Corrigenda
Corrigendum: Direct multiplexed measurement of gene expression with color-coded probe pairs - p709
Gary K Geiss, Roger E Bumgarner, Brian Birditt, Timothy Dahl, Naeem Dowidar, Dwayne L Dunaway, H Perry Fell, Sean Ferree, Renee D George, Tammy Grogan, Jeffrey J James, Malini Maysuria, Jeffrey D Mitton, Paola Oliveri, Jennifer L Osborn, Tao Peng, Amber L Ratcliffe, Philippa J Webster, Eric H Davidson & Leroy Hood
doi:10.1038/nbt0608-709c
Full Text - Corrigendum: Direct multiplexed measurement of gene expression with color-coded probe pairs | PDF (53 KB) - Corrigendum: Direct multiplexed measurement of gene expression with color-coded probe pairs
Naturejobs
Careers and Recruitment
Technology transfer and idea commercialization - pp711 - 712
Judith Sheft
doi:10.1038/nbt0608-711
Technology transfer professionals work at the interface of science and business to help move discoveries forward for the public good.
Abstract - | Full Text - Technology transfer and idea commercialization | PDF (217 KB) - Technology transfer and idea commercialization
