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Nature Biotechnology 26, 652–653 (1 June 2008) | doi:10.1038/nbt0608-652
Proteases' prime targets revealed
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Abstract
Much like the moving tumblers in a lock, the side chains in the active site of a protease interrogate proteins for cleavable peptide sequences. Most techniques for determining the substrate specificity of a particular protease reveal information only about residues on the non-prime side of the cleavage site, leaving the prime side unexplored.
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