1. Ian G. Woods and Alexander F. Schier are in the Department of Molecular and Cellular Biology, Broad Institute, Center for Brain Science, Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. e-mail: schier@fas.harvard.edu or e-mail: ianwoods@mcb.harvard.edu

Abstract

Directed gene knockout in a vertebrate has been achieved using zinc-finger nucleases.

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