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Nature Biotechnology 26, 525–526 (1 May 2008) | doi:10.1038/nbt0508-525

Flavivirus DNA vaccine with a kick

Alan D T Barrett

Dengue and West Nile viruses are major human pathogens for which there are no approved vaccines or antiviral drugs. Concerns about the safety of vaccination with inactivated or live attenuated viruses have stimulated interest in DNA vaccines, but thus far these have not proved sufficiently immunogenic.