Table of contents
Editorials
Looking forward, looking back - p475
doi:10.1038/nbt0508-475
Amgen's retrospective sortie into personalized Vectibix treatment poses some difficult questions for regulators concerning the oversight of companion diagnostics.
Abstract - | Full Text - Looking forward, looking back | PDF (114 KB) - Looking forward, looking back
Nothing to see here - p476
doi:10.1038/nbt0508-476
Based on one company's past poor publishing practices, a top-tier medical journal misguidedly stigmatizes any paper from industry.
Abstract - | Full Text - Nothing to see here | PDF (58 KB) - Nothing to see here
News
Regulators scramble to tighten loopholes after heparin debacle - pp477 - 478
Hepeng Jia
doi:10.1038/nbt0508-477
Full Text - Regulators scramble to tighten loopholes after heparin debacle | PDF (357 KB) - Regulators scramble to tighten loopholes after heparin debacle
EU to monitor for Chinese GM rice - p478
Brady Huggett
doi:10.1038/nbt0508-478
Full Text - EU to monitor for Chinese GM rice | PDF (70 KB) - EU to monitor for Chinese GM rice
Inhaled insulin's last gasp? - pp479 - 480
Jim Kling
doi:10.1038/nbt0508-479
Full Text - Inhaled insulin's last gasp? | PDF (184 KB) - Inhaled insulin's last gasp?
Courts deny Pfizer access - p480
Trisha Gura
doi:10.1038/nbt0508-480
Full Text - Courts deny Pfizer access | PDF (101 KB) - Courts deny Pfizer access
Patent threat in emerging economies shifts to biotech - pp481 - 483
Killugudi Jayaranam
doi:10.1038/nbt0508-481
Full Text - Patent threat in emerging economies shifts to biotech | PDF (169 KB) - Patent threat in emerging economies shifts to biotech
New Alzheimer's endpoints? - p482
Susan Aldridge
doi:10.1038/nbt0508-482a
Full Text - New Alzheimer's endpoints? | PDF (70 KB) - New Alzheimer's endpoints?
GM grass trials blocked - p482
Jeffrey L Fox
doi:10.1038/nbt0508-482b
Full Text - GM grass trials blocked | PDF (70 KB) - GM grass trials blocked
Bush pushes plant energy - p483
Jeffrey L Fox
doi:10.1038/nbt0508-483a
Full Text - Bush pushes plant energy | PDF (78 KB) - Bush pushes plant energy
Changes for ESAs - p483
B J Spalding
doi:10.1038/nbt0508-483b
Full Text - Changes for ESAs | PDF (78 KB) - Changes for ESAs
Dynavax trial halted - p484
Laura DeFrancesco
doi:10.1038/nbt0508-484a
Full Text - Dynavax trial halted | PDF (189 KB) - Dynavax trial halted
No way out for small public firms? - pp484 - 485
Peter Mitchell
doi:10.1038/nbt0508-484b
Full Text - No way out for small public firms? | PDF (251 KB) - No way out for small public firms?
IL-1 trap go-ahead - p485
Mark Ratner
doi:10.1038/nbt0508-485
Full Text - IL-1 trap go-ahead | PDF (120 KB) - IL-1 trap go-ahead
Data Page
Biotech slumps in Q1 - p486
Stacy Lawrence
doi:10.1038/nbt0508-486
Full Text - Biotech slumps in Q1 | PDF (150 KB) - Biotech slumps in Q1
News Feature
The special treatment - pp487 - 489
Randy Osborne
doi:10.1038/nbt0508-487
The special protocol assessment introduced only six years ago by the US Food and Drug Administration (FDA) to facilitate clinical trials is gaining popularity. Randy Osborne finds out why.
Abstract - | Full Text - The special treatment | PDF (209 KB) - The special treatment
Bioentrepreneur
Building a business
Learning from each other - pp491 - 494
Tim Sparey & Francesca Gliubich
doi:10.1038/bioe.2008.4
Opinion and Comment
Correspondence
HIV vaccine trials in India - p495
Seth Berkley
doi:10.1038/nbt0508-495
Full Text - HIV vaccine trials in India | PDF (138 KB) - HIV vaccine trials in India
Response to HIV vaccine trials in India - p496
doi:10.1038/nbt0508-496a
Full Text - Response to HIV vaccine trials in India | PDF (144 KB) - Response to HIV vaccine trials in India
Demonizing phytate - pp496 - 497
AbulKalam M Shamsuddin
doi:10.1038/nbt0508-496b
Full Text - Demonizing phytate | PDF (190 KB) - Demonizing phytate
Response to Demonizing phytate - pp497 - 498
doi:10.1038/nbt0508-497
Full Text - Response to Demonizing phytate | PDF (172 KB) - Response to Demonizing phytate
Legal issues for biological research standards - pp498 - 499
Jorge L Contreras
doi:10.1038/nbt0508-498
Full Text - Legal issues for biological research standards | PDF (210 KB) - Legal issues for biological research standards
Off the rails or on the mark? - pp499 - 500
Jack A Heinemann
doi:10.1038/nbt0508-499
Full Text - Off the rails or on the mark? | PDF (148 KB) - Off the rails or on the mark?
Off the rails or on the mark? - pp500 - 501
Joanna Chataway, Joyce Tait & David Wield
doi:10.1038/nbt0508-500
Full Text - Off the rails or on the mark? | PDF (80 KB) - Off the rails or on the mark?
Commentary
The impact of greed on academic medicine and patient care - pp503 - 507
John V Frangioni
doi:10.1038/nbt0508-503
Abstract - | Full Text - The impact of greed on academic medicine and patient care | PDF (275 KB) - The impact of greed on academic medicine and patient care
Features
Is personalized medicine finally arriving? - pp509 - 517
Malorye Allison
doi:10.1038/nbt0508-509
It's no gold rush, but dozens of players are emerging in personalized medicine, with biotechs, big and small, leading the way. Some big pharma companies and even payers remain skeptical, but economics aside, the real winners will be patients.
Abstract - | Full Text - Is personalized medicine finally arriving? | PDF (394 KB) - Is personalized medicine finally arriving?
Patents
Designing around patents: a guideline - pp519 - 522
Shyh-Jen Wang
doi:10.1038/nbt0508-519
An analysis of US Federal Circuit decisions shows strategies for designing around patents.
Abstract - | Full Text - Designing around patents: a guideline | PDF (166 KB) - Designing around patents: a guideline
Recent patent applications in drug screening - p523
doi:10.1038/nbt0508-523
Full Text - Recent patent applications in drug screening | PDF (41 KB) - Recent patent applications in drug screening
News and Views
Flavivirus DNA vaccine with a kick - pp525 - 526
Alan D T Barrett
doi:10.1038/nbt0508-525
Immunization with single-round infectious particles enhances potency of a DNA vaccine against West Nile virus.
Abstract - | Full Text - Flavivirus DNA vaccine with a kick | PDF (966 KB) - Flavivirus DNA vaccine with a kick
See also: Research by Chang et al.
Customized signaling with reconfigurable protein scaffolds - pp526 - 528
Patrick Guye & Ron Weiss
doi:10.1038/nbt0508-526
Engineering protein scaffolds creates signaling networks with novel properties.
Abstract - | Full Text - Customized signaling with reconfigurable protein scaffolds | PDF (547 KB) - Customized signaling with reconfigurable protein scaffolds
Retinal anti-angiogenesis by a new route - pp528 - 529
Roy Bicknell
doi:10.1038/nbt0508-528
A regulator of VEGF signaling shows therapeutic potential for retinal disease.
Abstract - | Full Text - Retinal anti-angiogenesis by a new route | PDF (213 KB) - Retinal anti-angiogenesis by a new route
Research highlights - p530
doi:10.1038/nbt0508-530
Full Text - Research highlights | PDF (111 KB) - Research highlights
Computational Biology
Analysis
A modular approach for integrative analysis of large-scale gene-expression and drug-response data - pp531 - 539
Zoltán Kutalik, Jacques S Beckmann & Sven Bergmann
doi:10.1038/nbt1397
Abstract - | Full Text - A modular approach for integrative analysis of large-scale gene-expression and drug-response data | PDF (1,171 KB) - A modular approach for integrative analysis of large-scale gene-expression and drug-response data | Supplementary information
Research
Perspective
The minimum information about a genome sequence (MIGS) specification - pp541 - 547
Dawn Field, George Garrity, Tanya Gray, Norman Morrison, Jeremy Selengut, Peter Sterk, Tatiana Tatusova, Nicholas Thomson, Michael J Allen, Samuel V Angiuoli, Michael Ashburner, Nelson Axelrod, Sandra Baldauf, Stuart Ballard, Jeffrey Boore, Guy Cochrane, James Cole, Peter Dawyndt, Paul De Vos, Claude dePamphilis, Robert Edwards, Nadeem Faruque, Robert Feldman, Jack Gilbert, Paul Gilna, Frank Oliver Glöckner, Philip Goldstein, Robert Guralnick, Dan Haft, David Hancock, Henning Hermjakob, Christiane Hertz-Fowler, Phil Hugenholtz, Ian Joint, Leonid Kagan, Matthew Kane, Jessie Kennedy, George Kowalchuk, Renzo Kottmann, Eugene Kolker, Saul Kravitz, Nikos Kyrpides, Jim Leebens-Mack, Suzanna E Lewis, Kelvin Li, Allyson L Lister, Phillip Lord, Natalia Maltsev, Victor Markowitz, Jennifer Martiny, Barbara Methe, Ilene Mizrachi, Richard Moxon, Karen Nelson, Julian Parkhill, Lita Proctor, Owen White, Susanna-Assunta Sansone, Andrew Spiers, Robert Stevens, Paul Swift, Chris Taylor, Yoshio Tateno, Adrian Tett, Sarah Turner, David Ussery, Bob Vaughan, Naomi Ward, Trish Whetzel, Ingio San Gil, Gareth Wilson & Anil Wipat
doi:10.1038/nbt1360
First Paragraph - | Full Text - The minimum information about a genome sequence (MIGS) specification | PDF (770 KB) - The minimum information about a genome sequence (MIGS) specification | Supplementary information
Brief Communications
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression - pp549 - 551
Stephen C Hyde, Ian A Pringle, Syahril Abdullah, Anna E Lawton, Lee A Davies, Anusha Varathalingam, Graciela Nunez-Alonso, Anne-Marie Green, Reto P Bazzani, Stephanie G Sumner-Jones, Mario Chan, Hongyu Li, Nelson S Yew, Seng H Cheng, A Christopher Boyd, Jane C Davies, Uta Griesenbach, David J Porteous, David N Sheppard, Felix M Munkonge, Eric W F W Alton & Deborah R Gill
doi:10.1038/nbt1399
First Paragraph - | Full Text - CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression | PDF (285 KB) - CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression | Supplementary information
Articles
Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina) - pp553 - 560
Diego Martinez, Randy M Berka, Bernard Henrissat, Markku Saloheimo, Mikko Arvas, Scott E Baker, Jarod Chapman, Olga Chertkov, Pedro M Coutinho, Dan Cullen, Etienne G J Danchin, Igor V Grigoriev, Paul Harris, Melissa Jackson, Christian P Kubicek, Cliff S Han, Isaac Ho, Luis F Larrondo, Alfredo Lopez de Leon, Jon K Magnuson, Sandy Merino, Monica Misra, Beth Nelson, Nicholas Putnam, Barbara Robbertse, Asaf A Salamov, Monika Schmoll, Astrid Terry, Nina Thayer, Ann Westerholm-Parvinen, Conrad L Schoch, Jian Yao, Ravi Barbote, Mary Anne Nelson, Chris Detter, David Bruce, Cheryl R Kuske, Gary Xie, Paul Richardson, Daniel S Rokhsar, Susan M Lucas, Edward M Rubin, Nigel Dunn-Coleman, Michael Ward & Thomas S Brettin
doi:10.1038/nbt1403
Abstract - | Full Text - Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina) | PDF (555 KB) - Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina) | Supplementary information
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics - pp561 - 569
Akin Akinc, Andreas Zumbuehl, Michael Goldberg, Elizaveta S Leshchiner, Valentina Busini, Naushad Hossain, Sergio A Bacallado, David N Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J Robert Dorkin, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G Rajeev, Dinah W Y Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans-Peter Vornlocher, Tracy S Zimmermann, Robert Langer & Daniel G Anderson
doi:10.1038/nbt1402
Abstract - | Full Text - A combinatorial library of lipid-like materials for delivery of RNAi therapeutics | PDF (987 KB) - A combinatorial library of lipid-like materials for delivery of RNAi therapeutics | Supplementary information
Letters
Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus - pp571 - 577
David C Chang, Wen J Liu, Itaru Anraku, David C Clark, Christopher C Pollitt, Andreas Suhrbier, Roy A Hall & Alexander A Khromykh
doi:10.1038/nbt1400
First Paragraph - | Full Text - Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus | PDF (830 KB) - Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus | Supplementary information
See also: News and Views by Barrett
The impact of target site accessibility on the design of effective siRNAs - pp578 - 583
Hakim Tafer, Stefan L Ameres, Gregor Obernosterer, Christoph A Gebeshuber, Renée Schroeder, Javier Martinez & Ivo L Hofacker
doi:10.1038/nbt1404
First Paragraph - | Full Text - The impact of target site accessibility on the design of effective siRNAs | PDF (287 KB) - The impact of target site accessibility on the design of effective siRNAs | Supplementary information
Naturejobs
Careers and Recruitment
Identifying a robust pool of leadership candidates - pp585 - 586
Bruce Rychlik
doi:10.1038/nbt0508-585
Strategies for finding the right hire in life-science recruiting.
Abstract - | Full Text - Identifying a robust pool of leadership candidates | PDF (69 KB) - Identifying a robust pool of leadership candidates
