Table of contents
April 2008, Volume 26 No 4 pp375-442
- In This Issue
- Editorials
- News
- Bioentrepreneur
- Opinion and Comment
- Features
- News and Views
- Computational Biology
- Research
- Naturejobs
Editorials
Doing better at doing good - p357
doi:10.1038/nbt0408-357
Global health initiatives should place greater emphasis on mechanisms for encouraging small and medium-sized biotech enterprises to participate in the fight against neglected diseases.
Abstract - Doing better at doing good | Full Text - Doing better at doing good | PDF (111 KB) - Doing better at doing good
A voice with no words - p358
doi:10.1038/nbt0408-358
The first blog from a biotech company goes live.
Abstract - A voice with no words | Full Text - A voice with no words | PDF (58 KB) - A voice with no words
News
US credit crunch impacts biotech across the globe - pp359 - 360
Peter Mitchell
doi:10.1038/nbt0408-359
Full Text - US credit crunch impacts biotech across the globe | PDF (427 KB) - US credit crunch impacts biotech across the globe
Dynogen's SPAC - p360
Randy Osborne
doi:10.1038/nbt0408-360
Can 'double blockbuster' strengthen Amgen's backbone? - pp361 - 363
Cormac Sheridan
doi:10.1038/nbt0408-361
Full Text - Can 'double blockbuster' strengthen Amgen's backbone? | PDF (280 KB) - Can 'double blockbuster' strengthen Amgen's backbone?
Four rebuffs for Cabilly - p362
Emily Waltz
doi:10.1038/nbt0408-362a
Full Text - Four rebuffs for Cabilly | PDF (82 KB) - Four rebuffs for Cabilly
India's IP snub - p362
KS Jayaraman
doi:10.1038/nbt0408-362b
Companies line up for hereditary angioedema market - pp364 - 365
Brady Huggett
doi:10.1038/nbt0408-364
Full Text - Companies line up for hereditary angioedema market | PDF (171 KB) - Companies line up for hereditary angioedema market
Tear-free onions - p365
Susan Aldridge
doi:10.1038/nbt0408-365a
Full Text - Tear-free onions | PDF (72 KB) - Tear-free onions
Thumbs up for Avastin - p365
BJ Spalding
doi:10.1038/nbt0408-365b
Full Text - Thumbs up for Avastin | PDF (72 KB) - Thumbs up for Avastin
Bush tails follow-ons - p366
Jeff Fox
doi:10.1038/nbt0408-366a
Full Text - Bush tails follow-ons | PDF (177 KB) - Bush tails follow-ons
Amgen's Japan deal - p366
Mark Ratner
doi:10.1038/nbt0408-366b
Full Text - Amgen's Japan deal | PDF (177 KB) - Amgen's Japan deal
Drug makers chase cancer stem cells - pp366 - 367
Charlie Schmidt
doi:10.1038/nbt0408-366c
Full Text - Drug makers chase cancer stem cells | PDF (222 KB) - Drug makers chase cancer stem cells
Profile
Dan Ravicher - p369
Crispin Littlehales
doi:10.1038/nbt0408-369
A patent attorney relies on guts, smarts and 'deep throats' to take on what he considers a broken patent system.
Abstract - Dan Ravicher | Full Text - Dan Ravicher | PDF (90 KB) - Dan Ravicher
News Feature
A mid-life crisis for aging theory - pp371 - 374
Ken Garber
doi:10.1038/nbt0408-371
From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs—but the sirtuin hypothesis is now coming under fire. Ken Garber reports.
Abstract - A mid-life crisis for aging theory | Full Text - A mid-life crisis for aging theory | PDF (156 KB) - A mid-life crisis for aging theory
Bioentrepreneur
Building a business
The seven deadly sins of business development - pp375 - 377
Jeffrey J Stewart & Ben Bonifant
doi:10.1038/bioe.2008.3
PDF (152 KB) - The seven deadly sins of business development
Opinion and Comment
Correspondence
An inconvenient version of events - p379
Giovanni Monastra
doi:10.1038/nbt0408-379a
Full Text - An inconvenient version of events | PDF (157 KB) - An inconvenient version of events
Response to An inconvenient version of events - pp379 - 380
doi:10.1038/nbt0408-379b
Full Text - Response to An inconvenient version of events | PDF (209 KB) - Response to An inconvenient version of events
Transendothelial movement and caveolae - pp380 - 381
Richard G W Anderson
doi:10.1038/nbt0408-380
Full Text - Transendothelial movement and caveolae | PDF (137 KB) - Transendothelial movement and caveolae
Response to Transendothelial movement and caveolae - pp381 - 382
doi:10.1038/nbt0408-381
Full Text - Response to Transendothelial movement and caveolae | PDF (96 KB) - Response to Transendothelial movement and caveolae
Expanding YIC status - pp382 - 383
Philippe Pouletty
doi:10.1038/nbt0408-382
Full Text - Expanding YIC status | PDF (152 KB) - Expanding YIC status
Bt corn in Spain—the performance of the EU's first GM crop - pp384 - 386
Manuel Gómez-Barbero, Julio Berbel & Emilio Rodríguez-Cerezo
doi:10.1038/nbt0408-384
Full Text - Bt corn in Spain—the performance of the EU's first GM crop | PDF (168 KB) - Bt corn in Spain—the performance of the EU's first GM crop | Supplementary information
Commentary
Newtons of the leaves of grass - pp387 - 389
Joachim Boldt & Oliver Müller
doi:10.1038/nbt0408-387
Abstract - Newtons of the leaves of grass | Full Text - Newtons of the leaves of grass | PDF (171 KB) - Newtons of the leaves of grass
Book Review
A bio-friendly future - p391
Linda MacDonald Glenn reviews A Many-Colored Glass: Reflections on the Place of Life in the Universe by Freeman J. Dyson
doi:10.1038/nbt0408-391
Full Text - A bio-friendly future | PDF (89 KB) - A bio-friendly future
Feature
Patents
Patenting pluripotence: the next battle for stem cell intellectual property - pp393 - 395
Katja Triller Vrtovec & Christopher Thomas Scott
doi:10.1038/nbt0408-393
What will be the impact of induced pluripotent stem cell discoveries on the current stem cell patent landscape?
Abstract - Patenting pluripotence: the next battle for stem cell intellectual property | Full Text - Patenting pluripotence: the next battle for stem cell intellectual property | PDF (105 KB) - Patenting pluripotence: the next battle for stem cell intellectual property
Recent patent applications in drug discovery automation - p396
doi:10.1038/nbt0408-396
Full Text - Recent patent applications in drug discovery automation | PDF (41 KB) - Recent patent applications in drug discovery automation
News and Views
Toward a renewable source of pancreatic 
-cells - pp397 - 398
Camillo Ricordi & Helena Edlund
doi:10.1038/nbt0408-397
Insulin-producing cells generated from human embryonic stem cells protect mice from diabetes.
Abstract - Toward a renewable source of pancreatic [beta]-cells | Full Text - Toward a renewable source of pancreatic 
-cells | PDF (222 KB) - Toward a renewable source of pancreatic -cells
See also: Research by Kroon et al.
Targeting siRNA to arrest fibrosis - pp399 - 400
Scott L Friedman
doi:10.1038/nbt0408-399
Vitamin A–mediated targeting of small interfering (si)RNA to stellate cells reverses liver cirrhosis.
Abstract - Targeting siRNA to arrest fibrosis | Full Text - Targeting siRNA to arrest fibrosis | PDF (1,841 KB) - Targeting siRNA to arrest fibrosis
See also: Research by Sato et al.
Cancer biomarker profiling with microRNAs - pp400 - 401
Stefanie S Jeffrey
doi:10.1038/nbt0408-400
MicroRNAs define tissues of origin in cancer.
Abstract - Cancer biomarker profiling with microRNAs | Full Text - Cancer biomarker profiling with microRNAs | PDF (191 KB) - Cancer biomarker profiling with microRNAs
See also: Research by Rosenfeld et al.
The oldest antibodies newly discovered - pp402 - 403
Zeev Pancer & Roy A Mariuzza
doi:10.1038/nbt0408-402
Lamprey monoclonal antibodies provide stable and high-avidity alternatives to immunoglobulins.
Abstract - The oldest antibodies newly discovered | Full Text - The oldest antibodies newly discovered | PDF (399 KB) - The oldest antibodies newly discovered
siRNAs with guts - pp403 - 405
Ian MacLachlan
doi:10.1038/nbt0408-403
Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.
Abstract - siRNAs with guts | Full Text - siRNAs with guts | PDF (1,824 KB) - siRNAs with guts
Research highlights - p406
doi:10.1038/nbt0408-406
Full Text - Research highlights | PDF (115 KB) - Research highlights
Computational Biology
Analysis
Discovering microRNAs from deep sequencing data using miRDeep - pp407 - 415
Marc R Friedländer, Wei Chen, Catherine Adamidi, Jonas Maaskola, Ralf Einspanier, Signe Knespel & Nikolaus Rajewsky
doi:10.1038/nbt1394
Abstract - Discovering microRNAs from deep sequencing data using miRDeep | Full Text - Discovering microRNAs from deep sequencing data using miRDeep | PDF (492 KB) - Discovering microRNAs from deep sequencing data using miRDeep | Supplementary information
Research
Perspective
Making it stick: convection, reaction and diffusion in surface-based biosensors - pp417 - 426
Todd M Squires, Robert J Messinger & Scott R Manalis
doi:10.1038/nbt1388
Abstract - Making it stick: convection, reaction and diffusion in surface-based biosensors | Full Text - Making it stick: convection, reaction and diffusion in surface-based biosensors | PDF (470 KB) - Making it stick: convection, reaction and diffusion in surface-based biosensors | Supplementary information
Brief Communications
Detecting native folds in mixtures of proteins that contain disulfide bonds - pp427 - 429
Mahesh Narayan, Ervin Welker, Huili Zhai, Xuemei Han, Guoqiang Xu, Fred W McLafferty & Harold A Scheraga
doi:10.1038/nbt1380
First Paragraph - Detecting native folds in mixtures of proteins that contain disulfide bonds | Full Text - Detecting native folds in mixtures of proteins that contain disulfide bonds | PDF (185 KB) - Detecting native folds in mixtures of proteins that contain disulfide bonds | Supplementary information
Articles
Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone - pp431 - 442
Yasushi Sato, Kazuyuki Murase, Junji Kato, Masayoshi Kobune, Tsutomu Sato, Yutaka Kawano, Rishu Takimoto, Kouichi Takada, Koji Miyanishi, Takuya Matsunaga, Tetsuji Takayama & Yoshiro Niitsu
doi:10.1038/nbt1396
Abstract - Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone | Full Text - Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone | PDF (1,148 KB) - Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone | Supplementary information
See also: News and Views by Friedman
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo - pp443 - 452
Evert Kroon, Laura A Martinson, Kuniko Kadoya, Anne G Bang, Olivia G Kelly, Susan Eliazer, Holly Young, Mike Richardson, Nora G Smart, Justine Cunningham, Alan D Agulnick, Kevin A D'Amour, Melissa K Carpenter & Emmanuel E Baetge
doi:10.1038/nbt1393
Abstract - Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells : in vivo | Full Text - Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo | PDF (1,956 KB) - Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo | Supplementary information
See also: News and Views by Ricordi & Edlund
Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors - pp453 - 461
Johannes L Zakrzewski, David Suh, John C Markley, Odette M Smith, Christopher King, Gabrielle L Goldberg, Robert Jenq, Amanda M Holland, Jeremy Grubin, Javier Cabrera-Perez, Renier J Brentjens, Sydney X Lu, Gabrielle Rizzuto, Derek B Sant'Angelo, Isabelle Riviere, Michel Sadelain, Glenn Heller, Juan Carlos Zúñiga-Pflücker, Chen Lu & Marcel R M van den Brink
doi:10.1038/nbt1395
Abstract - Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors | Full Text - Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors | PDF (491 KB) - Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors | Supplementary information
MicroRNAs accurately identify cancer tissue origin - pp462 - 469
Nitzan Rosenfeld, Ranit Aharonov, Eti Meiri, Shai Rosenwald, Yael Spector, Merav Zepeniuk, Hila Benjamin, Norberto Shabes, Sarit Tabak, Asaf Levy, Danit Lebanony, Yaron Goren, Erez Silberschein, Nurit Targan, Alex Ben-Ari, Shlomit Gilad, Netta Sion-Vardy, Ana Tobar, Meora Feinmesser, Oleg Kharenko, Ofer Nativ, Dvora Nass, Marina Perelman, Ady Yosepovich, Bruria Shalmon, Sylvie Polak-Charcon, Eddie Fridman, Amir Avniel, Isaac Bentwich, Zvi Bentwich, Dalia Cohen, Ayelet Chajut & Iris Barshack
doi:10.1038/nbt1392
Abstract - MicroRNAs accurately identify cancer tissue origin | Full Text - MicroRNAs accurately identify cancer tissue origin | PDF (322 KB) - MicroRNAs accurately identify cancer tissue origin | Supplementary information
See also: News and Views by Jeffrey
Erratum
Erratum: Vintage genetic engineering - p470
Laura DeFrancesco
doi:10.1038/nbt0408-470a
Full Text - Erratum: Vintage genetic engineering | PDF (51 KB) - Erratum: Vintage genetic engineering
Corrigendum
Corrigendum: Fluorogen-activating single-chain antibodies for imaging cell surface proteins - p470
Christopher Szent-Gyorgyi, Brigitte A Schmidt, Yehuda Creeger, Gregory W Fisher, Kelly L Zakel, Sally Adler, James A J Fitzpatrick, Carol A Woolford, Qi Yan, Kalin V Vasilev, Peter B Berget, Marcel P Bruchez, Jonathan W Jarvik & Alan Waggoner
doi:10.1038/nbt0408-470b
Full Text - Corrigendum: Fluorogen-activating single-chain antibodies for imaging cell surface proteins | PDF (51 KB) - Corrigendum: Fluorogen-activating single-chain antibodies for imaging cell surface proteins
Naturejobs
Careers and Recruitment
Almost in bloom - pp471 - 472
Emma Marris
doi:10.1038/nbt0408-471
St. Louis wants to become a hub of agricultural biotechnology. All it needs is more start-ups and funds.
Abstract - Almost in bloom | Full Text - Almost in bloom | PDF (104 KB) - Almost in bloom
