Table of contents
Editorial
Off the rails - p247
doi:10.1038/nbt0308-247
To restore its scientific credibility, the International Assessment of Agricultural Science and Technology for Development (IAASTD) should rethink its vision for biotech.
Abstract - | Full Text - Off the rails | PDF (107 KB) - Off the rails
News
Cloned animals deemed safe to eat, but labeling issues loom - pp249 - 250
Jeffrey L Fox
doi:10.1038/nbt0308-249
Full Text - Cloned animals deemed safe to eat, but labeling issues loom | PDF (433 KB) - Cloned animals deemed safe to eat, but labeling issues loom
Recombinant thrombin approved - p250
Mark Ratner
doi:10.1038/nbt0308-250
Full Text - Recombinant thrombin approved | PDF (90 KB) - Recombinant thrombin approved
Genzyme and Isis strike megadeal - pp251 - 253
George S. Mack
doi:10.1038/nbt0308-251
Full Text - Genzyme and Isis strike megadeal | PDF (304 KB) - Genzyme and Isis strike megadeal
Human embryos cloned - p252
Lisa Melton
doi:10.1038/nbt0308-252a
Full Text - Human embryos cloned | PDF (67 KB) - Human embryos cloned
BiDil flops - p252
Brady Huggett
doi:10.1038/nbt0308-252b
Start-ups weigh benefits of corporate incubators - pp254 - 255
Emily Waltz
doi:10.1038/nbt0308-254
Full Text - Start-ups weigh benefits of corporate incubators | PDF (215 KB) - Start-ups weigh benefits of corporate incubators
Another inhaled insulin casualty - p255
Susan Aldridge
doi:10.1038/nbt0308-255a
Full Text - Another inhaled insulin casualty | PDF (76 KB) - Another inhaled insulin casualty
Plant biotechs defect - p255
Susan Aldridge
doi:10.1038/nbt0308-255b
Full Text - Plant biotechs defect | PDF (76 KB) - Plant biotechs defect
HIV vaccine controversy - p256
KS Jayaraman
doi:10.1038/nbt0308-256a
Full Text - HIV vaccine controversy | PDF (98 KB) - HIV vaccine controversy
1000 Genomes project - p256
Nayanah Siva
doi:10.1038/nbt0308-256b
Full Text - 1000 Genomes project | PDF (98 KB) - 1000 Genomes project
Investor malaise stalks UK, European biotech - pp256 - 257
Peter Mitchell
doi:10.1038/nbt0308-256c
Full Text - Investor malaise stalks UK, European biotech | PDF (113 KB) - Investor malaise stalks UK, European biotech
Profile
Tony Conner - p259
Jim Kling
doi:10.1038/nbt0308-259
Public distaste for genetically modified crops shows little sign of abating. Tony Conner thinks he's found a solution: tailor crops to be more palatable to the public.
Abstract - | Full Text - Tony Conner | PDF (88 KB) - Tony Conner
Data Page
Brazil surpasses US in new transgenic crop plantings - p260
Stacy Lawrence
doi:10.1038/nbt0308-260
Full Text - Brazil surpasses US in new transgenic crop plantings | PDF (171 KB) - Brazil surpasses US in new transgenic crop plantings
News Feature
Vintage genetic engineering - pp261 - 263
Laura DeFrancesco
doi:10.1038/nbt0308-261
With the genome of the grapevine in hand, how likely are enologists and wine growers to resort to genetic engineering to tackle the problems facing viticulture? Laura DeFrancesco reports.
Abstract - | Full Text - Vintage genetic engineering | PDF (162 KB) - Vintage genetic engineering
Bioentrepreneur
Building a business
Entrepreneurial outreach - pp265 - 267
Rohit Shukla
doi:10.1038/bioe.2008.2
Opinion and Comment
Correspondence
Do amniotic fluid–derived stem cells differentiate into neurons in vitro? - pp269 - 270
Mauro Toselli, Elisabetta Cerbai, Ferdinando Rossi & Elena Cattaneo
doi:10.1038/nbt0308-269
Full Text - Do amniotic fluid–derived stem cells differentiate into neurons in vitro? | PDF (135 KB) - Do amniotic fluid–derived stem cells differentiate into neurons in vitro?
Response to Do amniotic fluid–derived stem cells differentiate into neurons in vitro? - pp270 - 271
doi:10.1038/nbt0308-270
Full Text - Response to Do amniotic fluid–derived stem cells differentiate into neurons in vitro? | PDF (96 KB) - Response to Do amniotic fluid–derived stem cells differentiate into neurons in vitro?
iPS cells and the politics of promise - pp271 - 272
Herbert Gottweis & Stephen Minger
doi:10.1038/nbt0308-271
Full Text - iPS cells and the politics of promise | PDF (173 KB) - iPS cells and the politics of promise
The 20-year African biotech plan - pp272 - 274
Jerome Amir Singh & Abdallah S Daar
doi:10.1038/nbt0308-272
Full Text - The 20-year African biotech plan | PDF (192 KB) - The 20-year African biotech plan | Supplementary information
BLOSUM62 miscalculations improve search performance - pp274 - 275
Mark P Styczynski, Kyle L Jensen, Isidore Rigoutsos & Gregory Stephanopoulos
doi:10.1038/nbt0308-274
Full Text - BLOSUM62 miscalculations improve search performance | PDF (182 KB) - BLOSUM62 miscalculations improve search performance | Supplementary information
Commentary
When biotech crosses borders - pp277 - 282
Elena Angulo & Ben Gilna
doi:10.1038/nbt0308-277
Abstract - | Full Text - When biotech crosses borders | PDF (406 KB) - When biotech crosses borders
Features
Chasing biotech across Europe - pp283 - 288
Barbara Nasto
doi:10.1038/nbt0308-283
European governments recognize that the biotech industry is important to their economic development, but can the sector overcome the obstacles hindering its growth?
Abstract - | Full Text - Chasing biotech across Europe | PDF (397 KB) - Chasing biotech across Europe | Supplementary information
Patents
Monsanto Technology LLC v. Cargill: a matter of construction - pp289 - 291
Simon Cohen & Gareth Morgan
doi:10.1038/nbt0308-289
For the first time, a genetically modified plant patent is litigated in the United Kingdom's High Court.
Abstract - | Full Text - Monsanto Technology LLC v. Cargill: a matter of construction | PDF (99 KB) - Monsanto Technology LLC v. Cargill: a matter of construction
Recent patent applications in microRNAs - p292
doi:10.1038/nbt0308-292
Full Text - Recent patent applications in microRNAs | PDF (40 KB) - Recent patent applications in microRNAs
News and Views
Digital mRNA profiling - pp293 - 294
Paolo Fortina & Saul Surrey
doi:10.1038/nbt0308-293
Color-coded probe pairs enable multiplexed gene expression analysis with a sensitivity that rivals PCR-based methods.
Abstract - | Full Text - Digital mRNA profiling | PDF (1,461 KB) - Digital mRNA profiling
See also: Research by Geiss et al.
A toolkit for the cell's powerhouse - pp294 - 296
Eric A Schon
doi:10.1038/nbt0308-294
Research on mitochondria will benefit from a new compendium of genetic and physiological data.
Abstract - | Full Text - A toolkit for the cell's powerhouse | PDF (508 KB) - A toolkit for the cell's powerhouse
See also: Research by Wagner et al.
Synthetic genomes brought closer to life - pp296 - 297
Robert A Holt
doi:10.1038/nbt0308-296
An entire bacterial genome has been reconstructed by stitching together chemically synthesized DNA fragments, bringing the prospect of an artificial living organism one step closer.
Abstract - | Full Text - Synthetic genomes brought closer to life | PDF (176 KB) - Synthetic genomes brought closer to life
Metabolic engineering delivers next-generation biofuels - pp298 - 299
Jay D Keasling & Howard Chou
doi:10.1038/nbt0308-298
The ability to produce 'higher-chain' alcohols in Escherichia coli could pave the way for advanced biofuels.
Abstract - | Full Text - Metabolic engineering delivers next-generation biofuels | PDF (158 KB) - Metabolic engineering delivers next-generation biofuels
Tiny tiles, tiny targets - pp299 - 300
David A Giljohann & Chad A Mirkin
doi:10.1038/nbt0308-299
A new label-free method for RNA detection uses programmable DNA tiles and atomic force microscopy.
Abstract - | Full Text - Tiny tiles, tiny targets | PDF (266 KB) - Tiny tiles, tiny targets
Research highlights - p301
doi:10.1038/nbt0308-301
Full Text - Research highlights | PDF (90 KB) - Research highlights
Computational Biology
Primer
What is principal component analysis? - pp303 - 304
Markus Ringnér
doi:10.1038/nbt0308-303
Principal component analysis is often incorporated into genome-wide expression studies, but what is it and how can it be used to explore high-dimensional data?
Abstract - | Full Text - What is principal component analysis? | PDF (289 KB) - What is principal component analysis?
Research
Perspective
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE) - pp305 - 312
Eric W Deutsch, Catherine A Ball, Jules J Berman, G Steven Bova, Alvis Brazma, Roger E Bumgarner, David Campbell, Helen C Causton, Jeffrey H Christiansen, Fabrice Daian, Delphine Dauga, Duncan R Davidson, Gregory Gimenez, Young Ah Goo, Sean Grimmond, Thorsten Henrich, Bernhard G Herrmann, Michael H Johnson, Martin Korb, Jason C Mills, Asa J Oudes, Helen E Parkinson, Laura E Pascal, Nicolas Pollet, John Quackenbush, Mirana Ramialison, Martin Ringwald, David Salgado, Susanna-Assunta Sansone, Gavin Sherlock, Christian J Stoeckert, Jr, Jason Swedlow, Ronald C Taylor, Laura Walashek, Anthony Warford, David G Wilkinson, Yi Zhou, Leonard I Zon, Alvin Y Liu & Lawrence D True
doi:10.1038/nbt1391
Abstract - | Full Text - Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE) | PDF (249 KB) - Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE) | Supplementary information
Brief Communications
Marked differences in differentiation propensity among human embryonic stem cell lines - pp313 - 315
Kenji Osafune, Leslie Caron, Malgorzata Borowiak, Rita J Martinez, Claire S Fitz-Gerald, Yasunori Sato, Chad A Cowan, Kenneth R Chien & Douglas A Melton
doi:10.1038/nbt1383
First Paragraph - | Full Text - Marked differences in differentiation propensity among human embryonic stem cell lines | PDF (200 KB) - Marked differences in differentiation propensity among human embryonic stem cell lines | Supplementary information
Articles
Direct multiplexed measurement of gene expression with color-coded probe pairs - pp317 - 325
Gary K Geiss, Roger E Bumgarner, Brian Birditt, Timothy Dahl, Naeem Dowidar, Dwayne L Dunaway, H Perry Fell, Sean Ferree, Renee D George, Tammy Grogan, Jeffrey J James, Malini Maysuria, Jeffrey D Mitton, Paola Oliveri, Jennifer L Osborn, Tao Peng, Amber L Ratcliffe, Philippa J Webster, Eric H Davidson, Leroy Hood & Krassen Dimitrov
doi:10.1038/nbt1385
Abstract - | Full Text - Direct multiplexed measurement of gene expression with color-coded probe pairs | PDF (379 KB) - Direct multiplexed measurement of gene expression with color-coded probe pairs | Supplementary information
See also: News and Views by Fortina & Surrey
Engineered lentivector targeting of dendritic cells for in vivo immunization - pp326 - 334
Lili Yang, Haiguang Yang, Kendra Rideout, Taehoon Cho, Kye il Joo, Leslie Ziegler, Abigail Elliot, Anthony Walls, Dongzi Yu, David Baltimore & Pin Wang
doi:10.1038/nbt1390
Abstract - | Full Text - Engineered lentivector targeting of dendritic cells for in vivo immunization | PDF (732 KB) - Engineered lentivector targeting of dendritic cells for in vivo immunization | Supplementary information
Letter
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein - pp335 - 341
Joerg Petersen, Maura Dandri, Walter Mier, Marc Lütgehetmann, Tassilo Volz, Fritz von Weizsäcker, Uwe Haberkorn, Lutz Fischer, Joerg-Matthias Pollok, Berit Erbes, Stefan Seitz & Stephan Urban
doi:10.1038/nbt1389
First Paragraph - | Full Text - Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein | PDF (525 KB) - Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein | Supplementary information
Resources
Large-scale chemical dissection of mitochondrial function - pp343 - 351
Bridget K Wagner, Toshimori Kitami, Tamara J Gilbert, David Peck, Arvind Ramanathan, Stuart L Schreiber, Todd R Golub & Vamsi K Mootha
doi:10.1038/nbt1387
Abstract - | Full Text - Large-scale chemical dissection of mitochondrial function | PDF (684 KB) - Large-scale chemical dissection of mitochondrial function | Supplementary information
See also: News and Views by Schon
Erratum
Erratum: Biotech patents still strong - p352
Stacey Lawrence
doi:10.1038/nbt0308-352a
Full Text - Erratum: Biotech patents still strong | PDF (48 KB) - Erratum: Biotech patents still strong
Corrigendum
Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells - p352
Fumitaka Osakada, Hanako Ikeda, Michiko Mandai, Takafumi Wataya, Kiichi Watanabe, Nagahisa Yoshimura, Akiori Akaike, Yoshiki Sasai & Masayo Takahashi
doi:10.1038/nbt0308-352b
Full Text - Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells | PDF (48 KB) - Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
Naturejobs
Careers and Recruitment
Developing China's homegrown biotechnology workforce - pp353 - 354
Grace Wong
doi:10.1038/nbt0308-353
All the elements are in place for China's leap into the global biotech sector.
Abstract - | Full Text - Developing China's homegrown biotechnology workforce | PDF (304 KB) - Developing China's homegrown biotechnology workforce
