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Nature Biotechnology 26, 1373–1378 (1 December 2008) | doi:10.1038/nbt.1507

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

Rong Fan , Ophir Vermesh , Alok Srivastava , Brian K H Yen , Lidong Qin , Habib Ahmad , Gabriel A Kwong , Chao-Chao Liu , Juliane Gould , Leroy Hood & James R Heath

As the tissue that contains the largest representation of the human proteome, blood is the most important fluid for clinical diagnostics. However, although changes of plasma protein profiles reflect physiological or pathological conditions associated with many human diseases, only a handful of plasma proteins are routinely used in clinical tests.