Brief Communications abstract
Nature Biotechnology 26, 1364 - 1366 (2008)
Published online: 23 November 2008 | doi:10.1038/nbt.1509
Human embryonic stem cells reveal recurrent genomic instability at 20q11.21
Nathalie Lefort1, Maxime Feyeux1, Cécile Bas2, Olivier Féraud3, Annelise Bennaceur-Griscelli3, Gerard Tachdjian2, Marc Peschanski1 & Anselme L Perrier1
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing 
23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.
- INSERM/UEVE UMR-861, I-STEM, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, 5 rue Henri Desbruères, 91030 Evry cedex, France.
- Service de biologie et génétique de la reproduction, INSERM U782, Hôpital Antoine Béclère, Université Paris 11, Clamart, France.
- INSERM U602/Université Paris-Sud 11, Hôpital Paul Brousse, Villejuif, France.
Correspondence to: Anselme L Perrier1 e-mail: aperrier@istem.genethon.fr
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Recurrent chromosomal abnormalities in human embryonic stem cellsNature Biotechnology Research (01 Dec 2008)
