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Volume 26 Issue 10, October 2008

'Stairs #2-Greece' by Wally Gilbert (http://wallygilbert.artspan.com; http://wallygilbert.30art.com; http://www.lulu.com/wallygilbert). A focus on next generation sequencing is presented on p 1097.

Volume 26 Issue 10

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Editorial

  • Researchers and their institutions need to dispel a myth about 'independent' research before the media does it for them.

    Editorial

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News

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Data Page

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Correspondence

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Commentary

  • Although new botanical drugs pose many challenges for both industry and the FDA, approval of the first botanical prescription drug shows they can be successfully met.

    • Shaw T Chen
    • Jinhui Dou
    • Susan Walker
    Commentary
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Book Review

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Patents

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News & Views

  • The ability to quantify carbon fluxes in mammalian cells is a step toward elucidating the dynamic metabolic networks associated with health and disease.

    • Uwe Sauer
    • Nicola Zamboni
    News & Views

  • Pancreatic acinar cells have been reprogrammed in vivo into insulin-expressing cells by adenoviral delivery of three transcription factors.

    • Michael S German
    News & Views

  • Global RNA interference screens uncover the host genes that support infection by HIV, West Nile virus and influenza virus.

    • Yueh-Ming Loo
    • Michael Gale Jr
    News & Views
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Editorial

  • The gobs of data produced by next-generation sequencing are a key problem limiting wider adoption.

    Editorial
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News

  • Launching the world's first commercial human genome sequencing center is currently the 'unreasonable' career ambition of sequencing-by-hybridization pioneer Rade Drmanac.

    • Laura DeFrancesco
    News
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News Feature

  • One bottleneck in next-generation sequencing is genomic sample selection. As research groups tackle the problem, companies are seizing a market opportunity. Ken Garber reports.

    • Ken Garber
    News Feature

  • Companies offering direct-to-consumer genomic information face tough questions about who regulates them, where they fit in health care and how to value their services. What will it take to move them from niche services to a broader customer base? Jeffrey Fox reports.

    • Jeffrey L Fox
    News Feature

  • Deep sequencing technology could soon be competitive with certain array applications. But the jury remains out on which of the myriad platforms will have the greatest impact and broadest application. Amy Coombs investigates.

    • Amy Coombs
    News Feature
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Commentary

  • The NHGRI's Advanced DNA Sequencing Technology program is spearheading the development of platforms that will bring routine whole-genome sequencing closer to reality.

    • Jeffery A Schloss
    Commentary
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Perspective

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Review Article

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Perspective

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Article

  • Penicillins and derived β-lactam antibiotics are essential in healthcare. To gain more insight into penicillin synthesis van den Berg and colleagues sequence and analyze the genome and transcriptome of the filamentous fungus Penicillium chrysogenum.

    • Marco A van den Berg
    • Richard Albang
    • Roel A L Bovenberg
    Article Open Access

  • The development of effective methods for generating cardiomyocytes from embryonic stem cells may prove useful in cell replacement therapies and drug screening. Chen et al. show that activation of Notch signaling efficiently converts hematopoietic progenitors derived from mouse embryonic stem cells into cardiovascular progenitors that give rise to large numbers of cardiomyocytes.

    • Vincent C Chen
    • Robert Stull
    • Gordon Keller
    Article

  • Munger et al. show that infection with human cytomegalovirus upregulates fatty acid biosynthesis and that pharmacological inhibition of this pathway inhibits replication of both this virus and influenza A. This approach, the first to reliably map major carbon fluxes in mammalian cells, extends the promise of metabolomics from diagnostic applications to identification of new therapeutic concepts.

    • Joshua Munger
    • Bryson D Bennett
    • Joshua D Rabinowitz
    Article
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Letter

  • The HIV-1 protein Vif, which promotes degradation of the host cell's antiviral APOBEC3 proteins, has yet to be targeted for therapeutic intervention. Nathans et al. use a high-throughput fluorescence screen to identify a small molecule that inhibits HIV replication in cultured cells by antagonizing Vif in an APOBEC3-dependent manner.

    • Robin Nathans
    • Hong Cao
    • Tariq M Rana
    Letter
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Corrigendum

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Careers and Recruitment

  • Venture capitalists have a key role in the translation of scientific innovation from idea to commercial reality.

    • Jason Brown
    Careers and Recruitment
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People

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Focus

  • A series of articles that focuses on the massively parallel sequencing technology that are making progress in the quest for a $1000 human genome sequence.

    Focus
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