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Research
Nature Biotechnology 26, 101–106 (1 January 2008) | doi:10.1038/nbt1374
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
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Abstract
Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of four transcription factors: Oct3/4, Sox2, Klf4 and c-Myc.
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