Figure 1 - Visualization of the yeast protein-protein interaction network showing the effect of multiple validation on networks derived from both the LC (Reguly et al.25) and the HC (Batada et al.7) datasets.
From the following article
Protein-protein interaction networks and biology—what's the connection?
Luke Hakes, John W Pinney, David L Robertson & Simon C Lovell
Nature Biotechnology 26, 69 - 72 (2008)
doi:10.1038/nbt0108-69
The HC dataset contains only those interactions observed at least twice; the data it was derived from are not available. Networks were visualized with LGL34.