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On the iTRAQ of kinase inhibitors

Nature Biotechnology volume 25, pages 994–996 (2007)Cite this article

Cellular targets of kinase inhibitors are identified by mass spectrometric analysis of binding to “kinobeads.”

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Figure 1: Cells or cell lysates are incubated with increasing concentrations of a given kinase inhibitor (such as imatinib) and kinases are isolated by affinity enrichment with kinobeads displaying broad-specificity kinase inhibitors.

Kim Caesar

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Authors and Affiliations

  1. Forest M. White is in the Biological Engineering Department and Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. fwhite@mit.edu,

    Forest M White

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  1. Forest M White
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White, F. On the iTRAQ of kinase inhibitors. Nat Biotechnol 25, 994–996 (2007). https://doi.org/10.1038/nbt0907-994

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