Perspective abstract

Nature Biotechnology 25, 894 - 898 (2007)
Published online: 8 August 2007 | doi:10.1038/nbt1324

The minimum information required for reporting a molecular interaction experiment (MIMIx)

Sandra Orchard1, Lukasz Salwinski2, Samuel Kerrien1, Luisa Montecchi-Palazzi1, Matthias Oesterheld3, Volker Stümpflen3, Arnaud Ceol4, Andrew Chatr-aryamontri4, John Armstrong5, Peter Woollard5, John J Salama6, Susan Moore6,7, Jérôme Wojcik8, Gary D Bader9, Marc Vidal10, Michael E Cusick10, Mark Gerstein11, Anne-Claude Gavin12, Giulio Superti-Furga13, Jack Greenblatt9, Joel Bader14, Peter Uetz15, Mike Tyers16, Pierre Legrain17, Stan Fields18, Nicola Mulder19, Michael Gilson20, Michael Niepmann21, Lyle Burgoon22, Javier De Las Rivas23, Carlos Prieto23, Victoria M Perreau24, Chris Hogue6, Hans-Werner Mewes3, Rolf Apweiler1, Ioannis Xenarios8, David Eisenberg2, Gianni Cesareni4 & Henning Hermjakob1

A wealth of molecular interaction data is available in the literature, ranging from large-scale datasets to a single interaction confirmed by several different techniques. These data are all too often reported either as free text or in tables of variable format, and are often missing key pieces of information essential for a full understanding of the experiment. Here we propose MIMIx, the minimum information required for reporting a molecular interaction experiment. Adherence to these reporting guidelines will result in publications of increased clarity and usefulness to the scientific community and will support the rapid, systematic capture of molecular interaction data in public databases, thereby improving access to valuable interaction data.

  1. European Molecular Biology Laboratory (EMBL) – European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK.
  2. UCLA–US Department of Energy Institute for Genomics & Proteomics, University of California, Los Angeles, California, USA.
  3. Institute for Bioinformatics, Forschungszentrum für Umwelt und Gesundheit – National Research Center for Environment and Health, Neuherberg, Germany.
  4. Department of Molecular Biology, University of Rome Tor Vergata, Rome, Italy.
  5. GlaxoSmithkline R&D, Stevenage, UK.
  6. Blueprint Initiative, Samuel Lunenfeld Research Institute, Ontario, Canada.
  7. National University of Singapore, Clinical Research Centre, Singapore.
  8. Merck Serono International S.A., Geneva, Switzerland.
  9. Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.
  10. Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  11. Molecular Biophysics and Biochemistry Department, Yale University, New Haven, Connecticut, USA.
  12. EMBL Heidelberg, Germany.
  13. CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  14. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  15. Institute of Toxicology and Genetics, Leopoldshafen, Forschungszentrum Karlsruhe, Germany.
  16. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
  17. Commissariat à l'Energie Atomique, Institut de Biologie et de Technologie de Saclay, Gif sur Yvette, France.
  18. Howard Hughes Medical Institute Department of Genome Sciences & Medicine, University of Washington, Seattle, Washington, USA.
  19. Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
  20. University of Maryland Biotechnology Institute, Rockville, Maryland, USA.
  21. University of Giessen, Germany.
  22. Toxicogenomic Informatics and Solutions, Lansing, Michigan, USA.
  23. Cancer Research Center (Centro de Investigación del Cancer, University of Salamanca and Consejo Superior de Investigaciones Científicas), Salamanca, Spain.
  24. Centre for Neuroscience, University of Melbourne, Victoria, Australia.

Correspondence to: Sandra Orchard1 e-mail:


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