Nature Biotechnology

Volume 25 Issue 7, July 2007

A model of two zinc-finger nucleases bound to DNA overlaid on an image of a metaphase chromosome spread. The side chains shown are key to the dimer interface of the cleavage domains, according to Miller et al. Two papers in this issue redesign the dimer interface to reduce off-target DNA cleavage. (pp 778 and 786) Credit: Jeffrey C. Miller

Volume 25 Issue 7

Editorial

Who speaks for small biotech?

The biotech industry's trade organizations need to better represent the concerns of their rank and file.

Editorial 01 Jul 2007

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News

GM giants pair up to do battle

Monsanto and BASF join forces to create second-generation GM crops.

Peter Mitchell
News 02 Jul 2007
Technology commercialization firms float in UK—but not elsewhere

British technology companies are uniquely turning to public markets rather than private investors.

Nuala Moran
News 02 Jul 2007
Industry waits for fallout from Cabilly

Should the Cabilly patent fall, more than its licensees will be affected.

Emily Waltz
News 02 Jul 2007
Production technologies change flu vaccine landscape

The first flu vaccine made in cell culture meets with the approval of the EMEA, as others move through company pipelines.

Cormac Sheridan
News 02 Jul 2007

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News in Brief

News in brief

News in Brief 02 Jul 2007

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News

Profile: Villoo Morawala Patell

Whether it's wooing investors, building a patent portfolio, critiquing multinational pharmaceutical firms or tackling hereditary diseases in her native community, Avesthagen CEO Villoo Morawala Patell brings a unique mix of dynamism and intellectual verve to the table.

K S Jayaraman
News 02 Jul 2007

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Data Page

State of the biotech sector—2006

Stacy Lawrence
Data Page 01 Jul 2007

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News Feature

Bad medicine

As more high-ticket biologic drugs reach the marketplace, the biotech industry may be increasingly beset by counterfeiters. Do regulators and law enforcement have the tools they need?

Cormac Sheridan
News Feature 02 Jul 2007

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Correspondence

Settling for second best?

Peter J Pitts
Correspondence 01 Jul 2007
Choosing crops as energy feedstocks

John R Porter
Mette Maj Norddahl Kirsch
Claus Felby
Correspondence 01 Jul 2007
The status of GM rice R&D in China

Yanqing Wang
Sam Johnston
Correspondence 01 Jul 2007
Recombinant protein solubility—does more mean better?

Nuria González-Montalbán
Elena García-Fruitós
Antonio Villaverde
Correspondence 01 Jul 2007

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Commentary

The MTA—rip it up and start again?

Securing material transfer agreements can be burdensome for academics and make downstream research prohibitively expensive, particularly for small startups with limited resources. Two technology-transfer professionals debate the pros and cons of such contracts.

Katharine Ku
James Henderson
Commentary 01 Jul 2007
Point: MTAs are the bane of our existence!

Katharine Ku
Commentary 01 Jul 2007
Counterpoint: MTAs are a practical necessity

James Henderson
Commentary 01 Jul 2007
Fatal flaws in agbiotech regulatory policies

The major national regulatory regimes for agbiotech products fail to satisfy scientific legitimacy on several counts.

Alan McHughen
Commentary 01 Jul 2007

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Book Review

Through the magnifying glass

Joel I Cohen
Book Review 01 Jul 2007

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Feature

Public biotech 2006—the numbers

Although biotech revenue and R&D spending continued to expand rapidly last year, profitability became a little more elusive.

Riku Lähteenmäki
Stacy Lawrence
Feature 01 Jul 2007

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Patents

Patents and translational research in genomics

Issues concerning gene patents may be impeding the translation of laboratory research to clinical use.

Jane Kaye
Naomi Hawkins
Jenny Taylor
Patents 01 Jul 2007
Recent patent applications in gene expression

Patents 01 Jul 2007

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News & Views

Precision genome surgery

A redesign of zinc-finger nucleases reduces off-target cleavage.

Alfred Pingoud
George H Silva
News & Views 01 Jul 2007
An evolved ribosome for genetic code expansion

Directed evolution of an orthogonal ribosome improves the efficiency of unnatural amino acid incorporation in vivo.

Caroline Köhrer
Uttam L RajBhandary
News & Views 01 Jul 2007
Loosening lignin's grip on biofuel production

Reducing lignin content in alfalfa can increase ethanol yields and decrease processing inputs.

Clint Chapple
Michael Ladisch
Rick Meilan
News & Views 01 Jul 2007
Human embryonic stem cells flock together

An international survey of human embryonic stem cell lines provides a benchmark for comparing results across laboratories.

M William Lensch
George Q Daley
News & Views 01 Jul 2007
NMR analysis goes nano

A new probe design increases the sensitivity of NMR.

John L Markley
News & Views 01 Jul 2007
Research highlights

News & Views 01 Jul 2007

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Primer

How do shotgun proteomics algorithms identify proteins?

Instrumentation aside, algorithms for matching mass spectra to proteins are at the heart of shotgun proteomics. How do these algorithms work, what can we expect of them and why is it so difficult to find protein modifications?

Edward M Marcotte

Collection:

Computational Biology
Primer 01 Jul 2007

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Brief Communication

Lignin modification improves fermentable sugar yields for biofuel production

Fang Chen
Richard A Dixon
Brief Communication 17 Jun 2007

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Article

Complete genome sequence of the fish pathogen Flavobacterium psychrophilum

Eric Duchaud
Mekki Boussaha
Abdenour Benmansour
Article Open Access 24 Jun 2007
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion

Kaihang Wang
Heinz Neumann
Jason W Chin
Article 24 Jun 2007
An improved zinc-finger nuclease architecture for highly specific genome editing

Jeffrey C Miller
Michael C Holmes
Edward J Rebar
Article 01 Jul 2007
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Michal Szczepek
Vincent Brondani
Toni Cathomen
Article 01 Jul 2007

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Letter

A universal RNAi-based logic evaluator that operates in mammalian cells

Keller Rinaudo
Leonidas Bleris
Yaakov Benenson
Letter 21 May 2007

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Resource

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

Oluseun Adewumi
Behrouz Aflatoonian
Glyn N Stacey
Resource 17 Jun 2007

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Careers and Recruitment

Translational investigators: life sciences' application engineers

New biotech therapies require researchers who can navigate the gap between the lab and the clinic.

Mari Paul
Careers and Recruitment 01 Jul 2007

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People

People

People 01 Jul 2007

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