Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Assisted suicide for retroviruses

Nature Biotechnology volume 25, pages 643–644 (2007)Cite this article

Antisense oligonucleotides activate the self-destruction of retroviruses in vivo.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Steps in the reverse transcription of retroviral RNA (red) to produce double-stranded DNA (dark and light blue), and the site of interference by oligodeoxynucleotides targeted to the polypurine tract.

References

  1. Matzen, K. et al. Nat. Biotechnol. 25, 669–674 (2007).

    Article  CAS  Google Scholar 

  2. Corey, D.R. Nat. Chem. Biol. 3, 8–11 (2007).

    Article  CAS  Google Scholar 

  3. Telesnitsky, A. & Goff, S.P. in Retroviruses (eds. J.M. Coffin, S.H. Hughes & H.E. Varmus) 121–160 (Cold Spring Harbor Press, Cold Spring Harbor, NY 1997).

    Google Scholar 

  4. Rausch, J.W. & Le Grice, S.F. Int. J. Biochem. Cell Biol. 36, 1752–1766 (2004).

    Article  CAS  Google Scholar 

  5. Jendis, J., Strack, B., Volkmann, S., Boni, J. & Moelling, K. AIDS Res. Hum. Retroviruses 12, 1161–1168 (1996).

    Article  CAS  Google Scholar 

  6. Jendis, J., Strack, B. & Moelling, K. AIDS Res. Hum. Retroviruses 14, 999–1005 (1998).

    Article  CAS  Google Scholar 

  7. Matskevich, A.A., Ziogas, A., Heinrich, J., Quast, S.A. & Moelling, K. AIDS Res. Hum. Retroviruses 22, 1220–1230 (2006).

    Article  CAS  Google Scholar 

  8. Richman, D.D. Nature 410, 995–1001 (2001).

    Article  CAS  Google Scholar 

  9. Temesgen, Z., Warnke, D. & Kasten, M.J. Expert Opin. Pharmacother. 7, 1541–1554 (2006).

    Article  CAS  Google Scholar 

  10. Kabat, D. Curr. Top. Microbiol. Immunol. 148, 1–42 (1989).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, Welkin E. Johnson is at the New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA. wjohnson@hms.harvard.edu,

    Welkin E Johnson

Authors
  1. Welkin E Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Johnson, W. Assisted suicide for retroviruses. Nat Biotechnol 25, 643–644 (2007). https://doi.org/10.1038/nbt0607-643

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0607-643

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing