Table 1
From the following article
Negotiating the RNAi patent thicket
Charlie Schmidt
Nature Biotechnology 25, 273 - 275 (2007) Published online: 1 March 2007
doi:10.1038/nbt0307-273
Table 1. Seminal patents in RNAi
| Patent | Patent number | Status | Date | Owner | Licensees | Coverage |
|---|---|---|---|---|---|---|
| Fire and Mellow | US 6,506,559 | Issued | January, 2004 | Carnegie Institute of Washington | Unrestricted | Inhibition of target genes with double-stranded RNA 25 nucleotides or more in length |
| Tuschl et al. (Tuschl I) | US 108,923 | Application pending | NA | UMass Medical School, MIT, Whitehead Institute, Max Planck Institute | Alnylam, Sirna, Cytrx | Inhibition of target genes with double-stranded RNA between 21 and 23 nucleotides in length. Includes overhangs, chemical modifications and data from mammalian cells |
| Tuschl et al. (Tuschl II) | US 7,056,704 | Issued | June, 2006 | Max Planck Institute | Alnylam | Short RNA fragments 19–23 nucleotides in length are sequence-specific mediators of RNAi in Drosophila melanogaster. Describes 3' overhangs |
| Tuschl et al. (Tuschl II) | US 7,078,196 | Issued | July, 2006 | Max Planck Institute | Alnylam | Second patent in Tuschl II series. Describes in greater detail the use of siRNA in mammalian cells |
| Crooke | US 6,107,094 | Issued | April, 2000 | Isis | Alnylam | Chemical modifications to stabilize RNA |
| Crooke | US 5,898,221 | Issued | April, 1999 | Isis | Alnylam | Chemical modifications to stabilize RNA |
| Benitec | US 6,573,099 | Issued then pulled for reexamination | June, 2003 (issuance date) | Benitec | Not available | Genetic constructs for delaying or repressing target gene using expressed system |
| Kreutzer-Limmer | EP 1,144,623 | Issued | 2002 | Alnylam | Not available | Describes RNAi in molecules from 15 to 21 nucleotides in length. Provides coverage in Europe, Australia and South Africa |