Table of contents
Editorials
Hearts and minds - p143
doi:10.1038/nbt0207-143
Abstract - Hearts and minds | Full Text - Hearts and minds | PDF (66 KB) - Hearts and minds
Life support for life science innovation? - p144
doi:10.1038/nbt0207-144
Abstract - Life support for life science innovation? | Full Text - Life support for life science innovation? | PDF (44 KB) - Life support for life science innovation?
News
Commercial interest grows in glycan analysis - pp145 - 146
Cormac Sheridan
doi:10.1038/nbt0207-145
Abstract - Commercial interest grows in glycan analysis | Full Text - Commercial interest grows in glycan analysis | PDF (386 KB) - Commercial interest grows in glycan analysis
Chinese biotech hamstrung by production issues - pp147 - 148
Hepeng Jia
doi:10.1038/nbt0207-147
Abstract - Chinese biotech hamstrung by production issues | Full Text - Chinese biotech hamstrung by production issues | PDF (176 KB) - Chinese biotech hamstrung by production issues
Next-generation sequencing outpaces expectations - p149
Catherine Shaffer
doi:10.1038/nbt0207-149
Abstract - Next-generation sequencing outpaces expectations | Full Text - Next-generation sequencing outpaces expectations | PDF (165 KB) - Next-generation sequencing outpaces expectations
Democrats prioritize pricing, generics and drug safety - pp150 - 151
Jeffrey L Fox
doi:10.1038/nbt0207-150
Abstract - Democrats prioritize pricing, generics and drug safety | Full Text - Democrats prioritize pricing, generics and drug safety | PDF (184 KB) - Democrats prioritize pricing, generics and drug safety
In Brief
News in brief - pp153 - 154
doi:10.1038/nbt0207-153
Profile: Jean-Paul Clozel - p155
Charlie Schmidt
doi:10.1038/nbt0207-155
Abstract - Profile: Jean-Paul Clozel | Full Text - Profile: Jean-Paul Clozel | PDF (71 KB) - Profile: Jean-Paul Clozel
Data Page
A stellar year for financing - p156
Stacy Lawrence
doi:10.1038/nbt0207-156
Full Text - A stellar year for financing | PDF (133 KB) - A stellar year for financing
News Feature
Reality check for device-drug convergence - pp157 - 159
Mark Ratner
doi:10.1038/nbt0207-157
Abstract - Reality check for device-drug convergence | Full Text - Reality check for device-drug convergence | PDF (183 KB) - Reality check for device-drug convergence
Bioentrepreneur
Building a business
Managing conflicts of interest: a survival guide for biotechs - pp161 - 163
Michael J Werner & Elizabeth Price
doi:10.1038/bioent915
PDF (88 KB) - Managing conflicts of interest: a survival guide for biotechs
Opinion and Comment
Correspondence
Blame factory farming, not organic food - p165
Craig Holdrege
doi:10.1038/nbt0207-165a
Full Text - Blame factory farming, not organic food | PDF (138 KB) - Blame factory farming, not organic food
Response to Blame factory farming, not organic food - pp165 - 166
doi:10.1038/nbt0207-165b
Full Text - Response to Blame factory farming, not organic food | PDF (154 KB) - Response to Blame factory farming, not organic food
The fit between organic and pharma crops in North Carolina - pp166 - 167
Claire G. Williams
doi:10.1038/nbt0207-166
Full Text - The fit between organic and pharma crops in North Carolina | PDF (156 KB) - The fit between organic and pharma crops in North Carolina
Response to The fit between organic and pharma crops in North Carolina - p167
doi:10.1038/nbt0207-167
Full Text - Response to The fit between organic and pharma crops in North Carolina | PDF (87 KB) - Response to The fit between organic and pharma crops in North Carolina
Genetically modified lignin below ground - pp168 - 169
David W. Hopkins, Elizabeth A. Webster, Wout Boerjan, Gilles Pilate & Claire Halpin
doi:10.1038/nbt0207-168
Full Text - Genetically modified lignin below ground | PDF (204 KB) - Genetically modified lignin below ground
Model for tuning GMO detection in seed and grain - pp169 - 170
Roy Macarthur, Alistair W. A. Murray, Theodore R. Allnutt, Carola Deppe, Heather J. Hird, Gerard M. Kerins, James Blackburn, Joy Brown, Robert Stones & Sarah Hugo
doi:10.1038/nbt0207-169
Full Text - Model for tuning GMO detection in seed and grain | PDF (162 KB) - Model for tuning GMO detection in seed and grain | Supplementary information
ATP and FRET—a cautionary note - pp170 - 172
Marieke Willemse, Edwin Janssen, Frank de Lange, Bé Wieringa & Jack Fransen
doi:10.1038/nbt0207-170
Full Text - ATP and FRET—a cautionary note | PDF (336 KB) - ATP and FRET—a cautionary note | Supplementary information
Commentary
Bringing antivenoms to Sub-Saharan Africa - pp173 - 177
Roberto P Stock, Achille Massougbodji, Alejandro Alagón & Jean-Philippe Chippaux
doi:10.1038/nbt0207-173
Abstract - Bringing antivenoms to Sub-Saharan Africa | Full Text - Bringing antivenoms to Sub-Saharan Africa | PDF (2,097 KB) - Bringing antivenoms to Sub-Saharan Africa
Book Review
Managing innovation in a global industry - p178
doi:10.1038/nbt0207-178
Full Text - Managing innovation in a global industry | PDF (91 KB) - Managing innovation in a global industry
Features
Turning biodefense dollars into products - pp179 - 184
Melanie C Trull, Tracey V du Laney & Mark D Dibner
doi:10.1038/nbt0207-179
Abstract - Turning biodefense dollars into products | Full Text - Turning biodefense dollars into products | PDF (272 KB) - Turning biodefense dollars into products
Patents
DNA patenting: the end of an era? - pp185 - 187
Michael M Hopkins, Surya Mahdi, Pari Patel & Sandy M Thomas
doi:10.1038/nbt0207-185
Abstract - DNA patenting: the end of an era? | Full Text - DNA patenting: the end of an era? | PDF (138 KB) - DNA patenting: the end of an era?
Recent patent applications in biomedical devices - p188
doi:10.1038/nbt0207-188
Full Text - Recent patent applications in biomedical devices | PDF (37 KB) - Recent patent applications in biomedical devices
News and Views
The genome of an industrial workhorse - pp189 - 190
Dan Cullen
doi:10.1038/nbt0207-189
Abstract - The genome of an industrial workhorse | Full Text - The genome of an industrial workhorse | PDF (130 KB) - The genome of an industrial workhorse
See also: Research by Pel et al.
Lentiviruses to the placental rescue - pp190 - 191
James C Cross
doi:10.1038/nbt0207-190
Abstract - Lentiviruses to the placental rescue | Full Text - Lentiviruses to the placental rescue | PDF (270 KB) - Lentiviruses to the placental rescue
See also: Research by Okada et al.
Calreticulin exposure increases cancer immunogenicity - pp192 - 193
Chris Clarke & Mark J Smyth
doi:10.1038/nbt0207-192
Abstract - Calreticulin exposure increases cancer immunogenicity | Full Text - Calreticulin exposure increases cancer immunogenicity | PDF (1,634 KB) - Calreticulin exposure increases cancer immunogenicity
Targeting brain-tumor stem cells - pp193 - 194
Roger Stupp & Monika E Hegi
doi:10.1038/nbt0207-193
Abstract - Targeting brain-tumor stem cells | Full Text - Targeting brain-tumor stem cells | PDF (794 KB) - Targeting brain-tumor stem cells
Research Highlights - p195
doi:10.1038/nbt0207-195
Full Text - Research Highlights | PDF (110 KB) - Research Highlights
Computational Biology
Analysis
Relating protein pharmacology by ligand chemistry - pp197 - 206
Michael J Keiser, Bryan L Roth, Blaine N Armbruster, Paul Ernsberger, John J Irwin & Brian K Shoichet
doi:10.1038/nbt1284
Abstract - Relating protein pharmacology by ligand chemistry | Full Text - Relating protein pharmacology by ligand chemistry | PDF (696 KB) - Relating protein pharmacology by ligand chemistry | Supplementary information
Research
Perspective
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo - pp207 - 215
Duncan E C Baker, Neil J Harrison, Edna Maltby, Kath Smith, Harry D Moore, Pamela J Shaw, Paul R Heath, Hazel Holden & Peter W Andrews
doi:10.1038/nbt1285
Abstract - Adaptation to culture of human embryonic stem cells and oncogenesis : in vivo | Full Text - Adaptation to culture of human embryonic stem cells and oncogenesis in vivo | PDF (325 KB) - Adaptation to culture of human embryonic stem cells and oncogenesis in vivo | Supplementary information
Brief Communications
Artificial reporter gene providing MRI contrast based on proton exchange - pp217 - 219
Assaf A Gilad, Michael T McMahon, Piotr Walczak, Paul T Winnard, Jr, Venu Raman, Hanneke W M van Laarhoven, Cynthia M Skoglund, Jeff W M Bulte & Peter C M van Zijl
doi:10.1038/nbt1277
First paragraph - Artificial reporter gene providing MRI contrast based on proton exchange | Full Text - Artificial reporter gene providing MRI contrast based on proton exchange | PDF (255 KB) - Artificial reporter gene providing MRI contrast based on proton exchange | Supplementary information
Article
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 - pp221 - 231
Herman J Pel, Johannes H de Winde, David B Archer, Paul S Dyer, Gerald Hofmann, Peter J Schaap, Geoffrey Turner, Ronald P de Vries, Richard Albang, Kaj Albermann, Mikael R Andersen, Jannick D Bendtsen, Jacques A E Benen, Marco van den Berg, Stefaan Breestraat, Mark X Caddick, Roland Contreras, Michael Cornell, Pedro M Coutinho, Etienne G J Danchin, Alfons J M Debets, Peter Dekker, Piet W M van Dijck, Alard van Dijk, Lubbert Dijkhuizen, Arnold J M Driessen, Christophe d'Enfert, Steven Geysens, Coenie Goosen, Gert S P Groot, Piet W J de Groot, Thomas Guillemette, Bernard Henrissat, Marga Herweijer, Johannes P T W van den Hombergh, Cees A M J J van den Hondel, Rene T J M van der Heijden, Rachel M van der Kaaij, Frans M Klis, Harrie J Kools, Christian P Kubicek, Patricia A van Kuyk, Jürgen Lauber, Xin Lu, Marc J E C van der Maarel, Rogier Meulenberg, Hildegard Menke, Martin A Mortimer, Jens Nielsen, Stephen G Oliver, Maurien Olsthoorn, Karoly Pal, Noël N M E van Peij, Arthur F J Ram, Ursula Rinas, Johannes A Roubos, Cees M J Sagt, Monika Schmoll, Jibin Sun, David Ussery, Janos Varga, Wouter Vervecken, Peter J J van de Vondervoort, Holger Wedler, Han A B Wösten, An-Ping Zeng, Albert J J van Ooyen, Jaap Visser & Hein Stam
doi:10.1038/nbt1282
Abstract - Genome sequencing and analysis of the versatile cell factory : Aspergillus niger: CBS 513.88 | Full Text - Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 | PDF (526 KB) - Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 | Supplementary information
See also: News and Views by Cullen
Letters
Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer - pp233 - 237
Yuka Okada, Yuko Ueshin, Ayako Isotani, Tomoko Saito-Fujita, Hisako Nakashima, Kazushi Kimura, Akira Mizoguchi, Masatsugu Oh-hora, Yoshiko Mori, Masato Ogata, Robert G Oshima, Masaru Okabe & Masahito Ikawa
doi:10.1038/nbt1280
First paragraph - Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer | Full Text - Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer | PDF (453 KB) - Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer | Supplementary information
See also: News and Views by Cross
Therapeutic targeting of a stem cell niche - pp238 - 243
Gregor B Adams, Roderick P Martin, Ian R Alley, Karissa T Chabner, Kenneth S Cohen, Laura M Calvi, Henry M Kronenberg & David T Scadden
doi:10.1038/nbt1281
First paragraph - Therapeutic targeting of a stem cell niche | Full Text - Therapeutic targeting of a stem cell niche | PDF (328 KB) - Therapeutic targeting of a stem cell niche | Supplementary information
High-throughput mapping of the chromatin structure of human promoters - pp244 - 248
Fatih Ozsolak, Jun S Song, X Shirley Liu & David E Fisher
doi:10.1038/nbt1279
First paragraph - High-throughput mapping of the chromatin structure of human promoters | Full Text - High-throughput mapping of the chromatin structure of human promoters | PDF (357 KB) - High-throughput mapping of the chromatin structure of human promoters | Supplementary information
Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging - pp249 - 253
R A Hoebe, C H Van Oven, T W J Gadella, Jr, P B Dhonukshe, C J F Van Noorden & E M M Manders
doi:10.1038/nbt1278
First paragraph - Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging | Full Text - Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging | PDF (452 KB) - Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging | Supplementary information
Erratum
Erratum: Rainbow biotech—South Africa's emerging sector - p254
Sabine Louët
doi:10.1038/nbt0207-254a
Full Text - Erratum: Rainbow biotech—South Africa's emerging sector | PDF (51 KB) - Erratum: Rainbow biotech—South Africa's emerging sector
Corrigenda
Corrigendum: Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes - p254
Alejandro Soto-Gutiérrez, Naoya Kobayashi, Jorge David Rivas-Carrillo, Nalu Navarro-Álvarez, Debaio Zhao, Teru Okitsu, Hirofumi Noguchi, Hesham Basma, Yashuhiko Tabata, Yong Chen, Kimiaki Tanaka, Michiki Narushima, Atsushi Miki, Tadayoshi Ueda, Hee-Sook Jun, Ji-Won Yoon, Jane Lebkowski, Noriaki Tanaka & Ira J Fox
doi:10.1038/nbt0207-254b
Full Text - Corrigendum: Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes | PDF (51 KB) - Corrigendum: Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes
Corrigendum: Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance - p254
Qi-Wen Niu, Shih-Shun Lin, Jose Luis Reyes, Kuan-Chun Chen, Hui-Wen Wu, Shyi-Dong Yeh & Nam-Hai Chua
doi:10.1038/nbt0207-254c
Full Text - Corrigendum: Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance | PDF (51 KB) - Corrigendum: Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance
Naturejobs
Careers and Recruitment
Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology - pp255 - 258
John Silvius
doi:10.1038/nbt0207-255
Abstract - Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology | Full Text - Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology | PDF (501 KB) - Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology



