Table 4 : The growth and potential of human antiviral monoclonal antibody therapeutics : Nature Biotechnology

From the following article

The growth and potential of human antiviral monoclonal antibody therapeutics

Wayne A Marasco & Jianhua Sui

Nature Biotechnology 25, 1421 - 1434 (2007) Published online: 7 December 2007

doi:10.1038/nbt1363

Table 4. Antiviral human mAb research in academic laboratories^{^a}

Viral family	Virus	Target	Antibody type/ development technology	First publication date	mAb^{^b}	Latest stage of study	Reference^{^c}
^aIt covers literatures published during 1995-2007 except for Abs against HIV. It may not be a complete list.
^bNamer of nAb or number of nAb(whole IgG) or antibody fragment being developed is listed.
^cFirst and latest publications were listed.
^dAnimal study in rodent.
^eAnimal study in non-human primate.
^fhMabs against HIV-1 have been extensively studied, only well-known broadly neutralizing antibodies (bcnAbs) and recently discovered bcnAbs are listed here.
		Envelope glycoprotein G2	Human, hybridoma	2000	1 nAb	In vitro	125
	Puumala hantavirus (PUUV)
		Envelope glycoprotein G1	Human, phage display antibody library from splenic lymphocytes of a splenectomized individual with PUUV	2000	1 nAb	in vitro	126
Bunyaviridae
	Hantaan virus (HTNV)	Envelope glycoprotein G2	Human, phage display antibody library from PBLs of four reconvalescent HFRS patients 2–3.5 months after onset	2000	5 nAbs	in vitro	127
		Envelope glycoprotein G1	Human, phage display antibody library from PBLs of a convalescent individual	2003	2 Fabs	in vitro	128
			Human, phage display antibody library from non-immune donors	2004	80R	in vivo^{^d}	62 64
Coronaviridae	SARS	Spike protein	Human, EBV+CpG 2006 immortalization of memory B cells	2004	S3.1	in vivo^{^d}	14
			Human, transgenic HuMab-Mouse	2005	mAb 201	in vivo^{^d}	12 129
			Human, phage display antibody library from non-immune donors	2007	m396	in vivo^{^d}	60 130
			Human, XenoMouse hybridoma	2007	8 nAbs	in vitro	11
Filoviridae
	Ebola	GP	Human, phage display antibody library from bone marrow of 2 donors recovered from infection	1999	KZ52	in vivo^{^e}	55 131
	WNV	DI/DII of E protein	Human, phage display antibody library from non-immune donors	2005	mAb no. 11	in vivo^{^d}	132
	Yellow fever virus	Envelope protein E	Human, phage display antibody library from individuals with yellow fever	2005	3 scFvs	in vitro	133
Flaviviridae
	Hepatitis C virus (HCV)	Envelope protein E2	Human, phage display antibody library from bone marrow of an individual chronically infected with HCV	2000	mAb 1:7 and A8	in vitro	134 135
		Envelope protein E1	Human, hybridoma	2004	H-111	In vitro	136
Hepadnaviridae	Hepatitis B virus (HBV)	Pre-S1 Surface antigen (HBsAg)	Human, phage display antibody library from non-immune donors	2005	G10	in vitro	137
			Human, phage display antibody library from vaccinated volunteers	2002	5 Fabs	in vitro	138
			Human, hybridoma	2000	3 nAbs	in vitro	139
Herpesviridae	VZV	Glycoprotein E	Human, phage display antibody library from PBLs of convalescent individual	2004	2 nAbs	in vitro	140
Orthomyxoviridae	Avian Influenza H5N1	Hemagglutinin	Human, EBV+CpG 2006 immortalization of memory B cells	2007	4 nAbs	in vivo^{^d}	15
			Chimeric	2006	2 nAbs	in vivo^{^d}	141
	RSV	F protein	Humanized	1995	RSHZ19	in vivo^{^d}	142
	Hendra (HeV) and Nipah virus (NiV)	Envelope glycoprotein	Human, phage display antibody library from non-immune donors	2006	7 nAbs	in vitro	143
Paramyxoviridae
	Measles	Hemogglutinin (H) protein	Human, phage display antibody library from bone marrow or splenic lymphocytes of three MV-immune individuals	2002	3 Fabs	In vitro	144
Parvoviridae	Parvovirus B19	Minor capsid protein VP1, major capsid protein VP2 or non-structural protein NS1	Human, hybridoma	1999	4 nAbs	in vitro	145
Picornaviridae	Hepatitis A virus (HAV)	Viral structure protein VP1 and VP3	Human, phage display antibody library from PBLs of 7 HAV-immune donors	2004	HA6 and HA9	in vitro	146
	Vaccinia virus (B5)	Envelope B5 protein	Chimpanzee/human, phage display antibody library from immunized chimpanzee bone marrow-derived lymphocytes	2006	2 nAbs	in vivo^{^d}	147
Poxviridae	Vaccinia virus	Unidentified	Human, phage antibody display library from PBLs of vaccinia virus (VACV)-immune donor	1999	6 Fabs	in vitro	148
	Vaccinia virus (A33)	Envelope A33 protein	Chimpanzee/human, phage display antibody library from immunized chimpanzee bone marrow-derived lymphocytes	2007	4 nAbs	in vivo^{^d}	149
Reoviridae	Rotavirus	Viral outer capsid protein 4 and 7 (VP4 and VP7)	Human, phage display antibody library from B cells of tonsils, umbilical cord blood, peripheral blood, and bone marrow	2004	3 nAbs	in vitro	150
		CD4-binding site on gp120	Human, phage display antibody library from bone marrow of an asymptomatic individual (HIV⁺ for 6 years).	1991	b12	in vivo^{^e}	151 152
		Glycan cluster on gp120	Human, hybridoma	1994	2G12	Phase I and proof-of-principle efficacy study in human	153 154 155
	HIV-1^{^f}
Retroviridae		Membrane proximal region (MPR) on gp41	Human, hybridoma	1993	2F5	Same as 2G12	154 155 156
		MPR on gp41	Human, hybridoma	1994	4E10	Same as 2G12	153 154 155
		Envelope glycoprotein gp 120 or gp 41	Human, phage display antibody library from a donor with long term nonprogressive HIV-1 infection	2007	5 nAbs	in vitro	157
	HTLV-1	Gp46 of HTLV-1 and 2	Human, hybridoma	1997	8 Abs	in vitro	158
Rhabdoviridae	Rabies	Glycoprotein	Human, hybridoma	2000	8 nAbs	in vitro	159
			Human, phage display antibody library from PBLs of 6 vaccine-boosted donors	2005	2 Fabs	In vitro	160

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Table 4

From the following article

Table 4. Antiviral human mAb research in academic laboratoriesa

Table 4. Antiviral human mAb research in academic laboratories^{^a}