Brief Communications abstract
Nature Biotechnology 25, 1277 - 1279 (2007)
Published online: 14 October 2007 | doi:10.1038/nbt1351
Folate fortification of rice by metabolic engineering
Sergei Storozhenko1, Veerle De Brouwer2,4, Maarten Volckaert1,4, Oscar Navarrete1, Dieter Blancquaert1, Guo-Fang Zhang2,3, Willy Lambert2 & Dominique Van Der Straeten1
Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement.
- Unit Plant Hormone Signalling and Bio-imaging, Department of Molecular Genetics, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
- Laboratory of Toxicology, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
- Present address: Department of Nutrition, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106-4906, USA.
- These authors contributed equally to this work.
Correspondence to: Dominique Van Der Straeten1 e-mail: dominique.vanderstraeten@ugent.be
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